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Central and nephrogenic diabetes insipidus: updates on diagnosis and management.
Front Endocrinol (Lausanne)
January 2025
Department of Endocrinology, Walter Reed National Military Medical Center, Bethesda, MD, United States.
Diabetes insipidus (DI) is a rare endocrine disease involving antidiuretic hormone (ADH), encompassing both central and nephrogenic causes. Inability to respond to or produce ADH leads to inability of the kidneys to reabsorb water, resulting in hypotonic polyuria and, if lack of hydration, hypernatremia. DI cannot be cured and is an unfamiliar disease process to many clinicians.
View Article and Find Full Text PDFIncidence and Treatment of Arginine Vasopressin Deficiency (Central Diabetes Insipidus) in the Setting of Brain Death and Associations with Renal Function and Hemodynamics in Organ Donors.
J Clin Med
November 2024
Organ Donation Coordinator Unit, Medical Faculty, Leipzig University, University of Leipzig Medical Center, 04103 Leipzig, Germany.
: Arginine vasopressin deficiency (AVP-D) is a common condition in the setting of brain death. The aim of this study was to analyze the frequency of AVP-D in organ donors, its treatment, as well as the impact of AVP-D on hemodynamics and renal function. : This single-center, retrospective study included 63 organ donors treated between 2017 and 2022.
View Article and Find Full Text PDFRedefining Diagnostic Cut-Offs for the Indirect Water Deprivation Test.
Clin Endocrinol (Oxf)
February 2025
Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism Digestion and Reproduction, Imperial College London, London, UK.
Objective: An incorrect diagnosis of arginine vasopressin deficiency and resistance (AVP-D and AVP-R) results in the potentially dangerous use of desmopressin in healthy individuals. The water deprivation test is a central diagnostic test in patients with polydipsia polyuria syndrome (PPS). This study aims to determine the effectiveness of the current interpretation of reference ranges.
View Article and Find Full Text PDFProphylaxis in von Willebrand disease with von Willebrand factor concentrate and nonfactor therapies.
Res Pract Thromb Haemost
November 2024
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.
This manuscript summarizes the current status of prophylaxis and novel potential therapies to prevent bleeding in patients with von Willebrand disease (VWD). VWD is the most common inherited bleeding disorder, which is associated mainly with mucocutaneous bleeding and bleeding during surgical and dental interventions. More severely affected VWD patients, mostly those with type 2 and type 3, can also suffer from joint, muscle, and gastrointestinal bleeds.
View Article and Find Full Text PDFSelf-assembly, cytocompatibility, and interactions of desmopressin with sodium polystyrene sulfonate.
Soft Matter
December 2024
Departamento de Biofísica, Universidade Federal de São Paulo, São Paulo 04062-000, Brazil.
Peptide-polymer systems hold strong potential for applications in nanotherapeutics. Desmopressin, a synthetic analogue of the antidiuretic hormone arginine vasopressin, may serve as a valuable case of study in this context since it is a first-line treatment for disorders affecting water homeostasis, including diabetes insipidus. It also has an established use as a hemostatic agent in von Willebrand disease, and recently, its repurposing has been suggested as a neoadjuvant in the treatment of certain types of cancer.
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