We synthesized a series of novel pyrrole- and pyrazole-substituted coumarin derivatives and evaluated their antifungal activity against six phytopathogenic fungi in vitro. The primary assay results demonstrated that some designed compounds displayed potent activities. Among them, compounds 5g, 6a, 6b, 6c, 6d and 6h exhibited more effective control than Osthole against Cucumber anthrax and Alternaria leaf spot. Furthermore, compound 5g displayed stronger antifungal activity against Rhizoctorzia solani (EC = 15.4 µg/mL) than positive control Osthole (EC = 67.2 µg/mL).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11030-019-09920-z | DOI Listing |
Publication Analysis
Top Keywords
novel pyrrole-
8
pyrrole- pyrazole-substituted
8
pyrazole-substituted coumarin
8
coumarin derivatives
8
antifungal activity
8
control osthole
8
design synthesis
4
synthesis antifungal
4
antifungal activities
4
activities novel
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!