Signet ring cell (SRC) gastric cancer at advanced stage has poor prognosis. While a recent study reported nearly one-third of SRC cases contain tumors with deficient mismatch repair (MMR) genes, other studies in SRC have been inconclusive. To re-analyze the results, we performed immunohistochemical staining of MLH1, MSH2, MSH6 and PMS2 proteins in 38 SRC gastric tumors compared with 109 non-SRC (NSRC) tumors from 94 patients. In contrast to the previous study, all SRC gastric tumors normally expressed MMR proteins, whereas 22 of 109 of NSRC (20%) showed deficient MMR proteins. To reinforce our results, we referred to the Cancer Genome Atlas (TCGA) genomic database and found that only 6 (6%) of 99 samples with diffuse gastric tumors showed deficient MMR, whereas 64 (21%) of 304 in intestinal gastric tumors showed deficient MMR. Our results as well as the TCGA database indicated that MMR genes are infrequently inactivated in SRC gastric cancer. These findings indicate that SRC patients may not be the best candidates for immuno-oncology therapy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12032-019-1246-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Adolescents and Young Adults with Germline CDH1 Variants and the Risk of Overtreatment.
J Natl Cancer Inst
January 2025
Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Background: Adolescents and young adults (AYA) with germline CDH1 variants are at risk of overtreatment when precancer lesions are detected with endoscopic screening. We characterize diffuse-type gastric cancer prevalence and survival in AYA managed with prophylactic total gastrectomy (PTG) or endoscopic surveillance.
Methods: Prospective cohort study of 188 individuals aged 39 and younger enrolled from January 27, 2017, to May 1, 2023.
Zuojin Pill Alleviates Precancerous Lesions of Gastric Cancer by Modulating the MEK/ERK/c-Myc Pathway: An Integrated Approach of Network Pharmacology, Molecular Dynamics Simulation, and Experimental Validation.
Drug Des Devel Ther
December 2024
School of Basic Medical Sciences, Shaanxi University of Chinese Medicine, Xianyang, People's Republic of China.
Background: Precancerous lesions of gastric cancer (PLGC) represent critical stages in gastric cancer progression, with a high risk of malignancy. Current treatments, such as Helicobacter pylori eradication, show limited efficacy in reversing precancerous molecular changes. Zuojin Pill (ZJP), a traditional Chinese medicine, has demonstrated potential for treating digestive disorders and may offer a promising approach for PLGC intervention.
View Article and Find Full Text PDFSyk/Src/NF-κB axis is essentially targeted in anti-inflammatory and anti-gastritis effects of Bletilla striata ethanol extract.
J Ethnopharmacol
January 2025
Department of Integrative Biotechnology, and Biomedical Institute for Convergence at SKKU, Republic of Korea. Electronic address:
Ethnopharmacological Relevance: Traditional herbal medicine books "Shin Rhong Bon Cho Kyung" and "Hyang Yak Jip Sung Bang" mentioned that Bletilla striata (Thunb.) Rchb.f.
View Article and Find Full Text PDFCutaneous Metastases of Signet-Ring Cell Gastric Carcinoma: A Case Report.
Curr Health Sci J
September 2024
Ankara Etlik City Hospital, Department of Dermatology and Venereology, Ankara, Turkey.
Article Synopsis
- Cutaneous metastases from gastric carcinoma, specifically signet-ring cell (SRC) type, are rare but can indicate advanced disease or recurrence and may present as asymptomatic skin nodules that are easily misdiagnosed.
- Diagnosis relies on histopathological examination and specific staining techniques to confirm SRC tumors, which tend to spread aggressively and are resistant to chemotherapy.
- The presence of skin metastases is associated with a poor prognosis and necessitates a collaborative approach among healthcare providers for early detection and better patient outcomes.
NIT2 dampens BRD1 phase separation and restrains oxidative phosphorylation to enhance chemosensitivity in gastric cancer.
Sci Transl Med
November 2024
Department of Gastrointestinal Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
Article Synopsis
- 5-Fluorouracil (5-FU) resistance in gastric cancer is linked to low levels of the nitrilase family member 2 (NIT2), which plays a crucial role in overcoming this resistance through mechanisms unrelated to its metabolic functions.
- The study revealed that NIT2 interacts with BRD1, inhibiting harmful gene expression related to cellular energy production, leading to enhanced sensitivity to 5-FU treatment.
- Additionally, NIT2's presence is associated with better patient prognosis, and targeting oxidative phosphorylation with metformin can further improve the effectiveness of 5-FU in patients with low NIT2 levels.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!