A radical-promoted cyclization of methylthiolated alkynones with diverse radical precursors has been developed. This strategy occurred via a C(sp)-S bond formation and C(sp)-S cleavage sequence and allows an efficient synthesis of a variety of phosphoryl-, sulfenyl-, CFCOOEt-, and acyl-containing thiochromone derivatives in moderate to good yields under mild conditions.
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| http://dx.doi.org/10.1021/acs.orglett.9b00023 | DOI Listing |
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