[The alterations of cellular composition of blood and hormonal balance under adenocarcinoma of ascending part of colon as diagnostic criteria of development of processes of metastasis.].

The article presents the analysis of character of derangement of peripheral blood composition and blood immune status and their relationship with hormonal imbalance. The complex clinical laboratory examination was carried out covering 60 patients with local (T1-2 N0M0) and locally prevalent (T3-4 (а, b) N0M0, T3-4 (а, b) N1-2M0) stages of adenocarcinoma of ascending section of colon residing for treatment in the clinic of surgery and oncology at the base of Non-State Institution of Health Care "The Road Clinical Hospital at the Station Saratov II" of The Public Corporation "Russian Railways" during 2012-2016. The diagnosis was verified using such common technique as colonoscopy with express-cytological analysis. The distribution of patients on observation groups was implemented after operative treatment (right-side hemicolectomy) and by results of planned pathomorphological analysis. The comparative evaluation was carried out concerning cellular composition of peripheral blood, sub-population composition of lymphocytes and content in blood of adrenocorticotropin, cortisol and somatotropic hormone. The pathogenic relationship is established between progressively increasing of level of cortisol in blood of patients, immunodeficiency on T- and then on B-system of lymphocytes, increasing of level of somatotropic hormone and development of local metastases. The diagnostic criteria of transition of local stage of adenocarcinoma of ascending part of colon to locally prevalent form is progressively increasing content of cortisol, adrenocorticotropin and somatotropic hormone in blood against the background of increasing lymphopenia, monocytopenia, T-dependent immunodeficiency. The monitoring of indices of level of lymphocytes, monocytes of blood and their sub-population composition, content of cortisol and somatotropic hormone in blood can be used as criteria of prevalence of neoplasia in case of clinically non-manifesting metastases.