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A Review of the Histopathology of Nail Unit Tumors Including Selection of the Optimal Surgical Sampling.
Skin Appendage Disord
December 2024
Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Background: A wide variety of tumors can affect the nail unit, with some commonly mistaken as inflammatory or infectious diseases. Obtaining an optimal sample for histopathologic evaluation requires understanding of nail unit anatomy as well as the histopathology of the suspected nail tumor.
Summary: This review discusses clinical and histopathologic features of a subset of benign and malignant nail tumors, including subungual melanoma, nail unit squamous cell carcinoma in situ, nail unit squamous cell carcinoma, onychomatricoma, onychopapilloma, onychocytic matricoma, and onychocytic carcinoma.
Clinical and dermoscopic features of onychomatricoma in Korean patients.
Australas J Dermatol
August 2024
Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Onychomatricomas: Assessing Surgical Outcomes.
Dermatol Surg
December 2024
Department of Dermatology, Saint-Pierre and Brugmann University Hospitals, Université Libre de Bruxelles, Brussels, Belgium.
Article Synopsis
- Onychomatricoma (OM) is a rare benign nail matrix tumor that requires surgical treatment, but there’s limited data on outcomes.
- A study reviewed 62 patients over 25 years, focusing on the relationship between the tumor's location, size, and postoperative results.
- The findings revealed that tangential excisions led to normal nail regrowth in 71% of cases, but tumors thicker than 3 mm or covering the entire nail plate had a higher risk of complications.
Intra-operative dermoscopy (onychoscopy) of the nail unit-A systematic review.
J Eur Acad Dermatol Venereol
October 2024
Department of Dermatology, Centre Hospitalier Lyon Sud, Lyon, France.
Article Synopsis
- Dermoscopy of the nail unit, or onychoscopy, is a non-invasive technique that enhances clinical diagnosis of nail-related conditions, currently used for both inflammatory and cancerous issues.
- Intra-operative onychoscopy allows doctors to visually inspect nail structures during surgery after the nail plate is removed, providing more detailed insights.
- A systematic review examining 19 studies with 218 cases highlighted conditions like melanoma and squamous cell carcinoma, but noted a limited number of studies with low evidence, emphasizing that it should complement, not replace, traditional histologic examinations.
Onychomatricoma in a patient with skin of color.
JAAD Case Rep
November 2023
Department of Dermatology, Baylor College of Medicine, Houston, Texas.
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