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SARS-CoV-2-specific CD8 T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years.
Proc Natl Acad Sci U S A
September 2024
Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Long COVID occurs in a small but important minority of patients following COVID-19, reducing quality of life and contributing to healthcare burden. Although research into underlying mechanisms is evolving, immunity is understudied. SARS-CoV-2-specific T cell responses are of key importance for viral clearance and COVID-19 recovery.
View Article and Find Full Text PDFAbstractCrown-of-thorns sea stars ( sp.) are among the most studied coral reef organisms, owing to their propensity to undergo major population irruptions, which contribute to significant coral loss and reef degradation throughout the Indo-Pacific. However, there are still important knowledge gaps pertaining to the biology, ecology, and management of sp.
View Article and Find Full Text PDFRobust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians.
Proc Natl Acad Sci U S A
October 2021
Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3000, Australia;
Morbidity and mortality rates from seasonal and pandemic influenza occur disproportionately in high-risk groups, including Indigenous people globally. Although vaccination against influenza is recommended for those most at risk, studies on immune responses elicited by seasonal vaccines in Indigenous populations are largely missing, with no data available for Indigenous Australians and only one report published on antibody responses in Indigenous Canadians. We recruited 78 Indigenous and 84 non-Indigenous Australians vaccinated with the quadrivalent influenza vaccine into the Looking into InFluenza T cell immunity - Vaccination cohort study and collected blood to define baseline, early (day 7), and memory (day 28) immune responses.
View Article and Find Full Text PDFThe origins of SARS-CoV-2: A critical review.
Cell
September 2021
Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK. Electronic address:
Article Synopsis
- A new virus similar to other viruses called coronaviruses was first noticed in Wuhan, China, in December 2019.
- Scientists are trying to figure out how this virus, named SARS-CoV-2, started spreading among people.
- There are two main ideas: one suggests it accidentally escaped from a lab, and the other says it came from animals.
Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients.
Nat Commun
May 2021
Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.
How innate and adaptive immune responses work in concert to resolve influenza disease is yet to be fully investigated in one single study. Here, we utilize longitudinal samples from patients hospitalized with acute influenza to understand these immune responses. We report the dynamics of 18 important immune parameters, related to clinical, genetic and virological factors, in influenza patients across different severity levels.
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