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The role of α-tocopherol in the prevention and treatment of Alzheimer's disease.
Mol Cell Biochem
January 2025
Department of Clinical Biochemistry and Laboratory Diagnostics, Institute of Medical Sciences, University of Opole, Oleska 48, 45-052, Opole, Poland.
Scientific reports from various areas of the world indicate the potential role of tocopherols (vitamin E) in particular α-tocopherol in the prevention and therapy of Alzheimer's disease. The current phenomenon is related to the growing global awareness of eating habits and is also determined by the need to develop the prevention, management and therapy of Alzheimer's disease. This article is a review of current research on the action of the active form of vitamin E-α-tocopherol and its impact on the development and course of Alzheimer's disease.
View Article and Find Full Text PDFThe potential link between the development of Alzheimer's disease and osteoporosis.
Biogerontology
January 2025
Department of Physiology, School of Medicine, University of Louisville, Louisville, KY, 40202, USA.
Alzheimer's disease (AD) and osteoporosis (OP) pose distinct but interconnected health challenges, both significantly impacting the aging population. AD, a neurodegenerative disorder characterized by memory impairment and cognitive decline, is primarily associated with the accumulation of abnormally folded amyloid beta (Aβ) peptides and neurofibrillary tangles in the brain. OP, a skeletal disorder marked by low bone mineral density, involves dysregulation of bone remodeling and is associated with an increased risk of fractures.
View Article and Find Full Text PDFVolumetry of Selected Brain Regions-Can We Compare MRI Examinations of Different Manufacturers and Field Strengths?
Clin Neuroradiol
January 2025
Department of Radiology and Neuroradiology, University Hospital of Schleswig-Holstein, Arnold-Heller-Str. 3, Hs D (Neurozentrum), 24105, Kiel, Germany.
Purpose: Magnetic Resonance Imaging based brain segmentation and volumetry has become an important tool in clinical routine and research. However the impact of the used hardware is only barely investigated. This study aims to assess the influence of scanner manufacturer, field strength and head-coil on volumetry results.
View Article and Find Full Text PDFBidirectional Mendelian Randomization Analysis of the Association Between Mitochondrial Proteins and Neurodegenerative Diseases.
Brain Behav
January 2025
Department of Neurosurgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
Background: Neurodegenerative diseases involve progressive neuronal dysfunction and cognitive decline, posing substantial global challenges. Although the precise causes remain unclear, several studies highlight the role of protein metabolism abnormalities in disease development. This study investigates the causal links between variations in mitochondrial protein genes and neurodegenerative diseases, aiming to elucidate their potential contributions to disease progression and identify novel therapeutic strategies.
View Article and Find Full Text PDFRole of insulin-like growth factor-2 in Alzheimer's disease induced memory impairment and underlying mechanisms.
Front Cell Neurosci
January 2025
Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China.
Alzheimer's disease (AD) is the most prevalent type of dementia. Treatments for AD do not reverse the loss of brain function; rather, they decrease the rate of cognitive deterioration. Current treatments are ineffective in part because they do not address neurotrophic mechanisms, which are believed to be critical for functional recovery.
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