AI Article Synopsis
- TGF-β plays a crucial role in tumor progression by influencing various processes such as cell growth, programmed cell death, and the spread of cancer.
- It is regulated by biological factors, signaling pathways, and microRNAs (miRNAs), which may help in classifying and diagnosing tumors.
- The review focuses on how these TGF-β-related miRNAs contribute to colorectal cancer (CRC) and aims to enhance understanding and treatment of the disease.
Article Abstract
Transforming growth factor β (TGF-β) modulates tumor progression by regulating cell proliferation, apoptosis, metastasis, angiogenesis, and drug resistance. Biological and pharmacological agonists/antagonists, the interplay between intracellular signaling pathways, and microRNAs (miRNAs) control the initiation and activation of the TGF-β signaling pathway. It has been proposed that the expression profiles of tumor suppressor and oncogenic TGF-β miRNAs may be used for the classification, diagnosis, and prognosis of human malignancies. Deregulated miRNAs and aberrant activation of TGF-β signaling are frequently found in human colorectal cancers (CRCs), but a little is known about their mechanisms of action in the development and progression of colorectal carcinoma. This review summarizes the current knowledge of the role of TGF-β signaling regulatory miRNAs in the pathogenesis of CRC for a better understanding and hence better management of this disease.
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| http://dx.doi.org/10.1002/jcp.28169 | DOI Listing |
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