Background: Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality all over the world. Acute exacerbation of COPD (AECOPD) not only accelerates the progression of disease, but also causes hospital administration and death events. Epidemiologic studies have shown air pollution is a high risk factor of AECOPD. However, there are rare technics or treatment strategies recommended to reduce severe air pollution related AECOPD.
Methods: This is a multi-center, prospective, randomized and standard treatment parallel control clinical trial. Seven hundred sixty-four stable COPD patients in group B, C and D according to GOLD 2017 will be recruited and equally divided into two parallel groups, salvational intervention (SI group) and control group (CT group). Original treatments for participants include tiotropium (18μg once q.d), budesonide/formoterol (160μg/4.5μg once or twice b.i.d) or budesonide/formoterol (160μg/4.5μg once or twice b.i.d) with tiotropium (18μg once q.d). The savational intervention for SI group is routine treatment plus budesonide/formoterol (160μg/4.5μg once b.i.d) from the first day after severe air pollution (air quality index, AQI ≥200) to the third day after AQI < 200. CT group will maintain the original treatment. The intervention will last for 2 years. Primary outcome is the frequency of AECOPD per year and the secondary outcomes include the incidence of unplanned outpatient visits, emergency visits, hospitalization, medical cost and mortality associated with AECOPD per year.
Discussion: The salvational intervention is a novel strategy for COPD management under severe air pollution. Results of the present study will provide reference information to guide clinical practice in reducing the air pollution related exacerbation of COPD.
Trial Registration: This study has been registered at www.ClinicalTrials.gov (registration identifier: NCT03083067 ) in 17 March, 2017.
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http://dx.doi.org/10.1186/s12890-018-0771-9 | DOI Listing |
BMC Public Health
January 2025
Department of Thoracic Surgery, the 2nd Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050000, PR China.
Background: Pulmonary space-occupying lesions are typical chronic pulmonary diseases that contribute significantly to healthcare resource use and impose a large disease burden in China. A time-series ecological trend study was conducted to investigate the associations between environmental factors and hospitalizations for pulmonary space-occupying lesions in North of China from 2014 to 2022.
Methods: The DLNM was used to quantify the association of environmental factors with lung cancer admissions.
Sci Rep
January 2025
Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto, 606-8585, Japan.
Phytotoxic air pollutants such as atmospheric nitrogen dioxide (NO) are among the major stresses affecting tree photosynthesis in urban areas. We clarified the relationship between NO concentrations and photosynthetic function for three major urban trees, Prunus × yedoensis, Rhododendron pulchrum, and Ginkgo biloba, planted in Kyoto and surrounding cities, combining our published data and new data collected from 2020 to 2023. High NO increased long-term water use efficiency for all species.
View Article and Find Full Text PDFPediatr Obes
January 2025
Epidemiology Branch, Division of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Background: Previous research observed links between prenatal air pollution and risk of childhood obesity but the timing of the exposure is understudied.
Aim: We examined prenatal particulate matter (PM, PM) exposure and child anthropometry.
Materials & Methods: Children's body mass index z-scores (zBMI) at 0-3 (N = 4370) and 7-9 (n = 1191) years were derived from reported anthropometry at paediatric visits.
Environ Res
January 2025
Department of Public Health, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China. Electronic address:
Background: Exposure to residential greenness has been linked with improved sleep duration; however, longitudinal evidence is limited, and the potential mediating effect of ambient fine particulate matter (PM) has yet to be assessed.
Methods: We obtained data for 19,567 participants across seven counties in a prospective cohort in Ningbo, China. Greenness was estimated using Normalized Difference Vegetation Index (NDVI) within 250-m, 500-m and 1000-m buffer zones, while yearly average PM concentrations were measured using validated land-use regression models, both based on individual residential addresses.
Ecotoxicol Environ Saf
January 2025
Division of Toxicology, Institute for Medical Research and Occupational Health, Zagreb 10000, Croatia.
Measurements of polycyclic aromatic hydrocarbons (PAHs) were simultaneously carried out at three different urban locations in Croatia (Zagreb, Slavonski Brod and Vinkovci) characterized as urban residential (UR), urban industrial (UI) and urban background (UB), respectively. This was done in order to determine seasonal and spatial variations, estimate dominant pollution sources for each area and estimate the lifetime carcinogenic health risks from atmospheric PAHs. Mass concentrations of PAHs showed seasonal variation with the highest values during the colder period and the lowest concentration during the warmer period of the year.
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