AI Article Synopsis
- Outer membrane vesicles (OMVs) are tiny structures from Gram-negative bacteria that play a significant role in interactions between bacteria and their hosts.
- OMVs carry various substances, including proteins and toxins, which can influence processes like biofilm formation and nutrient uptake.
- The text highlights recent research on how OMVs interact with host cells, particularly in the mouth and digestive system.
Article Abstract
Outer membrane vesicles (OMVs) are nanosized proteoliposomes derived from the outer membrane of Gram-negative bacteria. They are ubiquitously produced both in culture and during infection and are now recognized to play crucial roles during host-microbe interactions. OMVs can transport a broad range of chemically diverse cargoes, including lipids and lipopolysaccharides, membrane-embedded and associated proteins and small molecules, peptidoglycan, and nucleic acids. Particularly, virulence factors such as adhesins and toxins are often enriched in OMVs. Here we discuss a variety of ways in which OMVs facilitate host-microbe interactions, including their contributions to biofilm formation, nutrient scavenging, and modulation of host cell function. We particularly examine recent findings regarding OMV-host cell interactions in the oral cavity and the gastrointestinal tract.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352913 | PMC |
| http://dx.doi.org/10.1128/microbiolspec.PSIB-0001-2018 | DOI Listing |
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