AI Article Synopsis
- The study aimed to evaluate the effectiveness of checkpoint inhibitors in treating non-small-cell lung cancer (NSCLC) and rank the treatment outcomes.
- Researchers analyzed data from nine randomized trials with a total of 5,504 patients, focusing on three checkpoint inhibitors.
- The findings indicated that pembrolizumab combined with chemotherapy had the highest efficacy score and was better than pembrolizumab alone, although it resulted in more severe side effects without increasing treatment-related deaths.
Article Abstract
Aim: To estimate efficacy of checkpoint inhibitors and rank treatment effects in non-small-cell lung cancer.
Materials & Methods: Prospective randomized trials were included. p-score was used to rank treatment effects.
Results: A total of nine trials were identified, involving 5504 patients and three checkpoint inhibitors. Pembrolizumab plus chemotherapy had the highest p-score of 0.95 among all the treatments, and was superior to pembrolizumab alone (hazard ratio: 0.87; 95% CI: 0.79-0.95). Combination therapy had more grade 3-5 adverse events; but toxicity-related discontinuation and treatment-related death did not increase.
Conclusion: Pembrolizumab plus chemotherapy was likely to be the most effective treatment for patients with wild-type advanced NSCLC.
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| http://dx.doi.org/10.2217/imt-2018-0107 | DOI Listing |
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