AI Article Synopsis
- * Researchers discovered that ZIKV-specific human polyclonal antibodies, produced in transchromosomal bovines, show significant protection against ZIKV in knockout golden Syrian hamsters, both before and after infection.
- * The study suggests that these antibodies could be a rapid and effective way to combat Zika virus infections, showing promise as a treatment and prevention strategy in small animal models.
Article Abstract
Zika virus (ZIKV) infection can cause severe congenital diseases, such as microcephaly, ocular defects and arthrogryposis in fetuses, and Guillain⁻Barré syndrome in adults. Efficacious therapeutic treatments for infected patients, as well as prophylactic treatments to prevent new infections are needed for combating ZIKV infection. Here, we report that ZIKV-specific human polyclonal antibodies (SAB-155), elicited in transchromosomal bovine (TcB), provide significant protection from infection by ZIKV in knockout (KO) golden Syrian hamsters both prophylactically and therapeutically. These antibodies also prevent testicular lesions in this hamster model. Our data indicate that antibody-mediated immunotherapy is effective in treating ZIKV infection. Because suitable quantities of highly potent human polyclonal antibodies can be quickly produced from the TcB system against ZIKV and have demonstrated therapeutic efficacy in a small animal model, they have the potential as an effective countermeasure against ZIKV infection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410148 | PMC |
| http://dx.doi.org/10.3390/v11020092 | DOI Listing |
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