Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus.

Bioassay directed isolation of secondary metabolites from the rhizomes of (Fam. ‎Zingiberaceae) led to the isolation of mono-, sesqui-, and di-terpenes. The compounds were characterized as ()-8(17),12-labdadiene-15,16-dial (), zerumbol (), zerumbone (), buddledone A (), furanodienone (), germacrone (), borneol (), and camphor () by analysing one-dimensional (1D) (¹H and C) and two-dimensional (2D) (COSY, HSQC, HMBC, and NOESY) NMR data and mass spectra. Among these terpenes, compounds and revealed potential antibacterial activity (minimum inhibitory concentrations (MIC) values 32⁻128 µg/mL; 0.145⁻0.291 mM)) against a series of clinical isolates of multi-drug resistant (MDR) and Methicillin resistant (MRSA).