Although voltage-activated Ca channels are a common feature in excitable cells, their expression in cancer tissue is less understood. T-type Ca channels are particularly overexpressed in various cancers. Because of their activation profile at membrane potentials close to rest and the generation of a window current, T-type Ca channels may regulate a variety of Ca-dependent cellular processes, including cell proliferation, survival, and differentiation. The expression of T-type Ca channels is of special interest as a target for therapeutic interventions.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407089 | PMC |
http://dx.doi.org/10.3390/cancers11020134 | DOI Listing |
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