To determine if the mathematical model used for the estimation of critical force (CF) and the energy store component ' are applicable to intermittent isometric muscle actions of the finger flexors of rock climbers, using a multisession test. As a secondary aim, the agreement of estimates of CF and ' from a single-session test was also determined. The CF was defined as the slope coefficient, and ' was the intercept of the linear relationship between total "isometric work" () and time to exhaustion (). Subjects performed 3 (separated by either 20 min or >24 h) tests to failure using intermittent isometric finger-flexor contractions at 45%, 60%, and 80% of their maximum voluntary contraction. Force plotted against displayed a hyperbolic relationship; correlation coefficients of the parameter estimates from the work-time CF model were consistently very high ( > .94). Climbers' mean CF was 425.7 (82.8) N (41.0% [6.2%] maximum voluntary contraction) and ' was 30,882 (11,820) N·s. Good agreement was found between the single-session and multisession protocol for CF (intraclass correlation coefficient [ICC] = .900; 95% confidence interval, .616-.979), but not for ' (ICC = .768; 95% confidence interval, .190-.949). The results demonstrated the sensitivity of a simple test for the determination of CF and ', using equipment readily available in most climbing gyms. Although further work is still necessary, the test of CF described is of value for understanding exercise tolerance and to determine optimal training prescription to monitor improvements in the performance of the finger flexors.

Download full-text PDF

Source
http://dx.doi.org/10.1123/ijspp.2018-0809DOI Listing

Publication Analysis

Top Keywords

critical force
8
rock climbers
8
intermittent isometric
8
finger flexors
8
maximum voluntary
8
voluntary contraction
8
95% confidence
8
confidence interval
8
determination finger-flexor
4
finger-flexor critical
4

Similar Publications

Association between metabolic score for visceral fat index and BMI-adjusted skeletal muscle mass index in American adults.

Lipids Health Dis

January 2025

Department of Orthopedics, The 921st Hospital of the People's Liberation Army, The Second Affiliated Hospital of Hunan Normal University, Changsha, 410003, People's Republic of China.

Background: The metabolic score for visceral fat (METS-VF) is a recently identified index for evaluating visceral fat, also referred to as abdominal obesity. The skeletal muscle mass index (SMI) serves as a critical measure for assessing muscle mass and sarcopenia. Both obesity and the reduction of muscle mass can significantly affect human health.

View Article and Find Full Text PDF

Retention mechanism in slalom chromatography: Perspectives on the characterization of large DNA and RNA biopolymers in cell and gene therapy.

J Chromatogr A

January 2025

Waters Corporation, Instrument/Core Research/Fundamental, Milford, MA, 01757, USA. Electronic address:

Significant progress has been made in the last two decades in producing small (<2μm), high-purity, and low-adsorption particles, columns and system hardware, for ultra-high pressure liquid chromatography (UHPLC). Simultaneously, the recent rapid expansion of cell and gene therapies for treating diseases necessitates novel analytical technologies for analyzing large (>2 kbp) plasmid double-stranded (ds) DNA (which encodes for the in vitro transcription (IVT) of single-stranded (ss) mRNA therapeutics) and dsRNAs (related to IVT production impurities) biopolymers. In this context, slalom chromatography (SC), a retention mode co-discovered in 1988, is being revitalized using the most advanced column technologies for improved determination of the critical quality attributes (CQAs) of such new therapeutics.

View Article and Find Full Text PDF

Enzyme-enzyme interactions are fundamental to the function of cells. Their atomistic mechanisms remain elusive mainly due to limitations of in-cell measurements. We address this challenge by atomistically modeling, for a total of ≈80 μs, a slice of the human cell cytoplasm that includes three successive enzymes along the glycolytic pathway: glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphoglycerate kinase (PGK), and phosphoglycerate mutase (PGM).

View Article and Find Full Text PDF

Symmetry Breaking: Case Studies with Organic Cage-Racemates.

Acc Chem Res

January 2025

School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

ConspectusSymmetry is a pervasive phenomenon spanning diverse fields, from art and architecture to mathematics and science. In the scientific realms, symmetry reveals fundamental laws, while symmetry breaking─the collapse of certain symmetry─is the underlying cause of phenomena. Research on symmetry and symmetry breaking consistently provides valuable insights across disciplines, from parity violation in physics to the origin of homochirality in biology.

View Article and Find Full Text PDF

The mammalian high mobility group protein AT-hook 2 (HMGA2) is a small DNA-binding protein that specifically targets AT-rich DNA sequences. Structurally, HMGA2 is an intrinsically disordered protein (IDP), comprising three positively charged 'AT-hooks' and a negatively charged C-terminus. HMGA2 can form homodimers through electrostatic interactions between its 'AT-hooks' and C-terminus.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!