AI Article Synopsis
- Curcumin (Cur) has potential therapeutic benefits for cancer and chronic inflammatory diseases but is limited by its instability and low solubility in water.
- To improve these issues, researchers created curcumin-loaded polymeric nanoparticles (CNPs) that stabilize Cur and allow for a controlled release in the body.
- These CNPs not only enhance the stability of curcumin but also boost its antiangiogenic and anticancer effects, as demonstrated in chicken chorioallantoic membrane models.
Article Abstract
Curcumin (Cur) has a wide range of bioactivities that show potential for the treatment of cancer as well as chronic diseases associated with inflammation and aging. However, the therapeutic efficacy of Cur has been hampered by its rapid degradation under physiological conditions and low aqueous solubility. To address these problems, we prepared Cur-loaded polymeric nanoparticles (CNPs), in which Cur was complexed with phenylboronic acid-containing framboidal nanoparticles (NPs), by simple mixing of Cur and NPs in an aqueous solution. CNPs showed improved chemical stability of Cur and released it in a sustained manner under physiological conditions. Furthermore, CNPs significantly enhanced the antiangiogenic and anticancer activities of Cur in chicken chorioallantoic membrane models.
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| http://dx.doi.org/10.1021/acs.bioconjchem.9b00006 | DOI Listing |
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