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A single-centre randomised controlled trial comparing the standard method and target-controlled infusion as a method of administering cefoxitin, which is used to prevent surgical site infections in colorectal surgical patients: study protocol.
Trials
January 2025
Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea.
Background: Prophylactic parenteral administration of antibiotics is strongly recommended to prevent surgical site infection (SSI). Cefoxitin is mainly administered intravenously in colorectal surgery. The current standard method for administering prophylactic antibiotics in adults is to administer a fixed dose quickly before skin incision.
View Article and Find Full Text PDFEffect of buprenorphine delivered by target-controlled infusion on the minimum alveolar concentration of isoflurane in cats.
Vet Anaesth Analg
January 2025
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
Objective: To characterize the effect of buprenorphine on the minimum alveolar concentration of isoflurane (MACiso) in cats.
Study Design: Randomized, crossover, experimental study.
Animals: A group of six healthy male neutered cats, aged 2-8 years with body mass 5.
Clinical evaluation of bispectral index-guided closed-loop infusion of propofol for preschool children: A multi-center randomized controlled study.
Pediatr Investig
December 2024
Department of Anesthesiology Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China.
Importance: The closed-loop infusion system can automatically adjust and maintain the depth of anesthesia by using the propofol target-controlled infusion (TCI) model under the feedback guidance of the bispectral index (BIS).
Objective: To evaluate the safety and superiority of closed-loop TCI of propofol guided by BIS during maintenance of generalized intravenous anesthesia for preschool children.
Methods: A total of 120 children aged 1-6 years were enrolled and were divided into a closed-loop feedback group (Group C) and an open-loop manual control group (Group O), with 60 participants in each group.
Comparison of target concentration of propofol during three phases of live donor liver transplant surgery using a target-controlled infusion of propofol total intravenous anaesthesia - A prospective, observational pilot study.
Indian J Anaesth
November 2024
Department of Anaesthesia, Institute of Liver and Biliary Sciences, Delhi, India.
Article Synopsis
- This study explores how the pharmacokinetics of propofol—specifically its required concentrations—varies in different phases (dissection, anhepatic, and neohepatic) during liver transplantation.
- It involved 20 patients with chronic liver disease, and used a target-controlled infusion method to adjust propofol levels based on the bispectral index (BIS), which measures consciousness levels.
- Results showed that the mean target concentration of propofol was highest during the dissection phase, significantly decreasing during the anhepatic and neohepatic phases, indicating a need for lower propofol dosages in those latter stages.
Influence of the type of anaesthesia on acute kidney injury after nephrectomy: a randomised controlled trial.
Anaesthesia
November 2024
Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Article Synopsis
- The study investigates the impact of maintenance anaesthetics (propofol vs. desflurane) on acute kidney injury (AKI) following nephrectomy in patients with renal cell carcinoma.
- A total of 317 patients were analyzed, with a 25% incidence of postoperative AKI, showing no significant difference between the propofol group (27%) and the desflurane group (23%).
- The conclusion suggests that the choice of anaesthetic does not influence AKI risk, indicating that future research should focus on other modifiable factors contributing to AKI in these patients.
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