In a randomized double-blind, cross-over experiment, 0.5 g/kg of ethanol in the form of white wine and 3 g of L-carnitine by intravenous infusion were administered to 15 healthy volunteers. Ethanol and acetate plasma levels and the urine concentrations of acetylcarnitine were determined. Administration of ethanol induced a significant increase of both plasma ethanol and acetate, lasting 6-8 hr. The concomitant administration of carnitine resulted in a significant decrease of plasma acetate, whereas plasma ethanol levels remained unmodified. Urinary acetylcarnitine content significantly increased following administration of ethanol plus carnitine, but not when L-carnitine alone was administered. The resulting conclusion is that administered L-carnitine might trap excess acetyls derived both from free acetate, formed by ethanol oxidation, and from acetyl coenzyme A, accumulated as a result of the ethanol-induced decrease in the Krebs cycle flux.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1530-0277.1988.tb00259.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Whole stillage inclusion level influences in vitro fiber digestibility and ruminal fermentation of tall fescue hay.
J Anim Sci
January 2025
Department of Animal and Food Sciences, University of Kentucky, Lexington, KY 40546, USA.
With the growing bourbon industry in the southeastern U.S. leading to increased production of liquid distillery byproducts, there is a pressing need to explore sustainable uses for whole stillage [containing residual grain (corn, rye, malted barley) and liquid after ethanol separation] in livestock nutrition.
View Article and Find Full Text PDFPhytochemical analysis and biological activities of solvent extracts and silver nanoparticles obtained from Woodwardia unigemmata (Makino) Nakai.
PLoS One
January 2025
Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
Multidrug resistant bacteria are causing health problems and economic burden worldwide; alternative treatment options such as natural products and nanoparticles have attained great attention recently. Therefore, we aimed to determine the phytochemicals, antibacterial potential, and anticancer activity of W. unigemmata.
View Article and Find Full Text PDFNot All Antiseptic Solutions Are Equivalent in Removing Biofilm: A Comparison Across Different Orthopaedic Surfaces.
J Bone Joint Surg Am
January 2025
Adult Reconstruction and Joint Replacement, Hospital for Special Surgery, New York, NY.
Background: Antiseptic solutions are commonly utilized during total joint arthroplasty (TJA) to prevent and treat periprosthetic joint infection (PJI). The purpose of this study was to investigate which antiseptic solution is most effective against methicillin-sensitive Staphylococcus aureus (MSSA) and Escherichia coli biofilms established in vitro on orthopaedic surfaces commonly utilized in total knee arthroplasty: cobalt-chromium (CC), oxidized zirconium (OxZr), and polymethylmethacrylate (PMMA).
Methods: MSSA and E.
Fructose catabolism and its metabolic effects: Exploring host-microbiota interactions and the impact of ethnicity.
J Physiol
January 2025
Department of Internal and Experimental Vascular Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Important health disparities are observed in the prevalence of obesity and associated non-communicable diseases (NCDs), including type 2 diabetes (T2D) and metabolic dysfunction-associated steatotic liver disease (MASLD) among ethnic groups. Yet, the underlying factors accounting for these disparities remain poorly understood. Fructose has been widely proposed as a potential mediator of these NCDs, given that hepatic fructose catabolism can result in deleterious metabolic effects, including insulin resistance and hepatic steatosis.
View Article and Find Full Text PDFEvaluation of the antiulcer activity of ethanolic extract and solvent fractions of Rupr. in experimental rats and their DART-ToF-MS profiling.
Nat Prod Res
January 2025
Advanced Materials Research Chair, Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
In this study, antiulcer activity of ethanolic extract and solvent fractions of the aerial part of was investigated using ethanol-induced model of gastric ulceration in rats. The results showed that ethyl acetate, non-polar components and diethyl ether fractions have a remarkable antiulcerogenic activity; because they exhibited control-ulcer protection by 85.2%, 77.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!