Bioaccessibility of β-Lactoglobulin Nanoemulsions Containing Coenzyme Q: Impact of Droplet Size on the Bioaccessibility of Coenzyme Q.

Korean J Food Sci Anim Resour

Department of Animal Bioscience (Institute of Agriculture and Life Science), Gyeongsang National University, Jinju 52828, Korea.

Published: December 2018

The aims of this research were to examine the effect of heating temperature (65, 75, and 85℃) and CaCl concentration level (3, 4, and 5 mM) on the physicochemical properties of β-lactoglobulin (β-lg) nanoemulsions (NEs) and to study how the droplet size of NEs affects the bioaccessibility (BA) of coenzyme Q (CoQ). The droplet size of NEs and BA of CoQ was assessed by particle size analyzer and UV-Vis spectrophotometer, respectively. An increase in heating temperature and CaCl concentration level resulted in a significant (p<0.05) increase in the droplet size of NEs while there were no significant differences in polydispersity index and zeta-potential of NEs. When NEs containing CoQ were incubated in simulated small intestinal phases, an increase in the droplet size and polydispersity index of NEs was observed. This indicated that NEs were not stable in small intestine and digestion of NEs occurred. As heating temperature and CaCl concentration level were decreased, a significant (p<0.05) increase in BA of CoQ was observed. There was a significant (p<0.05) increase in BA of CoQ with a decrease in the droplet size of NEs. In conclusion, heating temperature and CaCl concentration level were key-parameters affecting the initial droplet size of NEs and BA of CoQ was negatively correlated with initial droplet size of NEs.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335127PMC
http://dx.doi.org/10.5851/kosfa.2018.e65DOI Listing

Publication Analysis

Top Keywords

droplet size
12
bioaccessibility coenzyme
8
heating temperature
8
cacl concentration
8
concentration level
8
size nes
8
bioaccessibility β-lactoglobulin
4
β-lactoglobulin nanoemulsions
4
nanoemulsions coenzyme
4
coenzyme impact
4

Similar Publications

Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side effect of anticancer agents with limited effective preventive or therapeutic interventions. Although fenofibrate, a peroxisome proliferator-activated receptor-alpha (PPARα) agonist, has demonstrated neuroprotective and analgesic properties, its clinical utility is hindered by low receptor affinity, poor subtype selectivity, and suboptimal bioavailability. A190, a highly selective and potent nonfibrate PPARα agonist, offers a promising alternative but is limited by poor aqueous solubility, resulting in reduced oral bioavailability and therapeutic efficacy.

View Article and Find Full Text PDF

Capillary vibrating sharp-edge spray ionization (cVSSI) has been used to control the droplet charging of nebulized microdroplets and monitor effects on protein ion conformation makeup as determined by mass spectrometry (MS). Here it is observed that the application of voltage results in noticeable differences to the charge state distributions (CSDs) of ubiquitin ions. The data can be described most generally in three distinct voltage regions: Under low-voltage conditions (<+200 V, LV regime), low charge states (2+ to 4+ ions) dominate the mass spectra.

View Article and Find Full Text PDF

Interaction of cesium compounds with abundant inorganic compounds of atmosphere: Effect on cloud formation potential and settling.

J Hazard Mater

January 2025

Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Mumbai 400085, India; Homi Bhabha National Institute, Anushaktinagar, Mumbai 400094, India.

Experiments were conducted in controlled laboratory conditions to determine the size-resolved CCN (Cloud Condensation Nuclei) activity of sub micrometer-sized aerosols containing nuclear fission products (CsI and CsOH) and abundant ambient inorganic aerosols ammonium sulphates ((NH)SO), ammonium chloride (NHCl), sodium nitrate (NaNO), and sodium chloride (NaCl). The presence of these atmospheric-relevant compounds internally mixed with fission product compounds has the potential to affect the capacity of ambient particulates of aerosols to absorb water and function as CCN. Once in the atmosphere, the dynamics of airborne radionuclides and subsequently their fate gets affected by dry and wet deposition processes.

View Article and Find Full Text PDF

Ionization and fragmentation are at the core of mass spectrometry. But they are not necessarily separated in space, as in-source fragmentation can also occur. Here, we survey the literature published since our 2005 review on the internal energy and fragmentation in electrospray ionization sources.

View Article and Find Full Text PDF

Mitochondrial function is crucial for hepatic lipid metabolism. Current research identifies two types of mitochondria based on their contact with lipid droplets: peridroplet mitochondria (PDM) and cytoplasmic mitochondria (CM). This work aimed to investigate the alterations of CM and PDM in metabolic dysfunction-associated steatotic liver disease (MASLD) induced by spontaneous type-2 diabetes mellitus (T2DM) in db/db mice.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!