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Cutaneous Metastasis of Bladder Cancer: A Systematic Review.
Cureus
November 2024
Department of Obstetrics and Gynecology, Beaumont Hospital, Dearborn, USA.
Bladder cancer is one of the main causes of urogenital cancer (30-35% of the total urological cancers). Although metastases from urologic tumors are rare, it is associated with a high mortality rate. The location and pattern of metastasis are random and unpredictable.
View Article and Find Full Text PDFAtypical Presentation of Rapidly Progressive Cutaneous Metastases of Clear Cell Renal Carcinoma: A Case Report.
Medicina (Kaunas)
November 2024
Clinic of Dermatology, Elias Emergency University Hospital, 011461 Bucharest, Romania.
Cutaneous metastases from clear cell renal carcinoma (ccRC) are uncommon and often indicate a poor prognosis. These metastases typically occur on the scalp, face, and trunk, and they can be difficult to diagnose due to their resemblance to benign dermatological tumors. We report the case of a 56-year-old patient with a history of ccRC (TNM stage 4) who was referred to our dermatology department with two rapidly enlarging, painful lesions on the left jawline and scalp, which had developed one month and one week earlier, respectively.
View Article and Find Full Text PDFStage III xanthogranulomatous pyelonephritis with sarcomatoid degeneration.
Radiol Case Rep
December 2024
Department of Radiology, Ospedale del Mare, ASL NA1 Centro, Naples, Italy.
Article Synopsis
- Xanthogranulomatous pyelonephritis (XGP) is a rare chronic kidney condition linked to factors like kidney stones, diabetes, and recurrent infections, with a potential risk of cancer in up to 11% of cases.
- A 76-year-old woman presented with abdominal and back pain; imaging revealed a nonfunctioning kidney with necrotic areas and a nephron-cutaneous fistula, indicating advanced XGP.
- This case highlights the importance of using multiple imaging methods, such as MDCT and contrast-enhanced ultrasound, for accurately diagnosing and managing patients with XGP, especially when suspicious masses are found.
A Case Series of Primary Cutaneous Sarcomatoid Carcinoma With Aberrant Smooth Muscle Actin Expression: A Clinicopathologic and Immunophenotypic Study.
Am J Dermatopathol
August 2024
Departments of Pathology and Dermatology, Columbus, OH.
Article Synopsis
- Primary cutaneous sarcomatoid squamous cell carcinoma (PCSSCC) can be difficult to diagnose due to its similarities with other spindle cell tumors and atypical expressions of markers like smooth muscle actin (SMA).
- A study of 16 cases showed that these tumors were high-grade and typically involved deeper skin layers, with most cases exhibiting atypical spindle and epithelioid cell patterns.
- The research highlights the importance of using multiple epithelial markers for accurate diagnosis, while also noting that SMA expression can complicate the identification process.
TRPS1 Expression Is Frequently Seen in a Subset of Cutaneous Mesenchymal Neoplasms and Tumors of Uncertain Differentiation: A Potential Diagnostic Pitfall.
Dermatopathology (Basel)
July 2024
Department of Anatomic Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Article Synopsis
- The study investigates TRPS1 immunoreactivity in various cutaneous mesenchymal neoplasms and tumors of uncertain differentiation, highlighting gaps in existing research.
- Out of 135 analyzed cases, TRPS1 was found to be highly prevalent in dermatofibromas and atypical fibroxanthomas, while being less common in vascular tumors and absent in certain tumors like perineuriomas.
- The findings indicate significant differences in TRPS1 expression levels between AFXs and other tumor types, although it shows limited effectiveness in differentiating between atypical fibroxanthomas and sarcomatoid squamous cell carcinoma.
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