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PNPLA3 and SAMM50 variants are associated with lean nonalcoholic fatty liver disease in Asian population.
Ann Hepatol
December 2024
Department of Family Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Family Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Family Medicine, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, Taiwan. Electronic address:
Article Synopsis
- Lean adults with nonalcoholic fatty liver disease (NAFLD) face a higher risk of metabolic syndrome compared to lean individuals without the disease, prompting research into their clinical and genetic characteristics in Asian groups.
- A study involving 602 lean NAFLD patients and 1652 lean controls identified key genetic factors (rs738409 in PNPLA3 and rs3761472 in SAMM50) linked to increased NAFLD risk, even after accounting for body mass index (BMI) and metabolic syndrome.
- The findings highlight that these gene variations are significant predictors of fatty liver in lean populations, offering important insights for future research and potential health interventions.
The potential of insulin resistance indices to predict non-alcoholic fatty liver disease in patients with type 2 diabetes.
BMC Endocr Disord
December 2024
Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Article Synopsis
- The study investigates the effectiveness of the triglyceride-glucose (TyG) index and other insulin resistance markers in diagnosing non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM).
- A total of 268 T2DM patients were analyzed, comparing those with NAFLD to those without, and various blood indicators and insulin resistance indices were assessed using Receiver Operating Characteristic (ROC) analysis.
- Results indicated that four TyG-related parameters showed strong predictive performance for identifying NAFLD, with TyG-BMI being particularly effective, especially in males, showcasing a high sensitivity and predictive value.
Association between Weight-Adjusted Waist Index and Depression in NAFLD: the modulating roles of sex and BMI.
BMC Psychiatry
November 2024
Department of Psychological Medicine, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, Fujian, China.
Background: The Weight-Adjusted Waist Index (WWI) is a novel indicator of obesity that accurately reflects body composition. However, the association between WWI and depression in patients with non-alcoholic fatty liver disease (NAFLD) remains unclear. This study aims to explore this relationship through a nationally representative cross-sectional analysis.
View Article and Find Full Text PDFDiagnosis and Management of Lean Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Systematic Review.
Cureus
October 2024
Department of Medicine, Yale Affiliated Hospitals Program, New Haven, USA.
Article Synopsis
- * A literature search identified 95 relevant studies, revealing difficulties in diagnosing lean MASLD using traditional methods and highlighting the role of advanced imaging techniques.
- * The study recommends increased clinical awareness, regular monitoring, and tailored management strategies, such as lifestyle changes and potential medications, while calling for more research to improve diagnosis and treatment options.
Impact of PNPLA3 in Lean Individuals and in Cryptogenic Steatotic Liver Disease.
Liver Int
November 2024
Department of Gastroenterology and Hepatology, Saiseikai Suita Hospital, Suita, Japan.
Article Synopsis
- - MASLD, previously known as NAFLD, can affect people with normal body weight, splitting into two categories: lean MASLD (with cardiometabolic risk factors) and cryptogenic steatotic liver disease (without these factors).
- - Research shows that the PNPLA3 rs738409 genetic variant is more prevalent in individuals with lean NAFLD compared to those who are overweight or obese, but cardiometabolic risk factors usually still play a role in liver issues.
- - Although the PNPLA3 gene is linked to severe liver conditions and complications, its specific effects on lean individuals with NAFLD have not been thoroughly investigated.
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