Effects of tamoxifen on periodontal disease and Candida albicans of patients with breast cancer and other pathologies.

Unlabelled: Candida albicans is involved in periodontal disease, which is influenced by sex hormones.

Aim: To study the effects of the estrogen antagonist tamoxifen (TAM) on periodontal disease of oncological patients; clinical oral strains of C. albicans.

Patients: With periodontitis and breast cancer and other with AIDS were used.

Materials & Methods: Periodontal disease was evaluated by the academy of periodontology procedures and the growth of clinical C. albicans isolates were evaluated by the Clinical and Laboratory Standards Institute techniques.

Results: Women who consumed TAM for more than 2 years decreased periodontitis severity. In vitro, TAM inhibited the growth of both fluconazole-sensitive and resistant C. albicans.

Conclusion: Administered TAM chronically improves periodontal health and has antifungal activity on oral strains isolated from patients with odontologic and medical pathologies.