AI Article Synopsis
- Inbred mice, commonly used in biomedical research, face genetic limitations, prompting the study of a new strain (KWM/Hym) from Korean wild mice for better genetic diversity.
- Genetic analysis revealed that KWM/Hym displays significant differences from existing inbred strains, showing a high similarity (96.4%) to the PWK/PhJ strain.
- Morphometric measurements indicated KWM/Hym's unique physical traits, suggesting its potential as a valuable genetic resource for research and addressing the limitations of current lab mice.
Article Abstract
Laboratory inbred mice are used widely and commonly in biomedical research, but inbred mice do not have a big enough gene pool for the research. In this study, genetic and morphometric analyses were performed to obtain data on the characteristics of a newly developing inbred strain (KWM/Hym) captured from Chuncheon, Korea. All of five Korean wild male mice have the zinc-finger Y () gene. Also, all of 19 Korean wild mice used in this analysis have the AKV-type murine leukemia virus gene, indicating that Korean wild mice might be . To identify the genetic polymorphism in KWM/Hym, SNP analysis was performed. In a comparison with 28 SNP markers, there was a considerable difference between KWM/Hym and several inbred strains. The homogeneity between KWM/Hym and the inbred strains was as follows: C57BL/6J (39.3%), BALB/c AJic (42.9%), and DBA/2J (50%). KWM/Hym is most similar to the PWK/PhJ inbred strain (96.4%) derived from wild mice (Czech Republic). To identify the morphometric characteristics of KWM/Hym, the external morphology was measured. The tail ratio of male and female was 79.60±3.09 and 73.55±6.14%, respectively. KWM/Hym has short and agouti-colored hairs and its belly is white with golden hair. Taking these results together, KWM/Hym, a newly developing inbred mouse originated from wild mouse, might be use as new genetic resources to overcome the limitations of the current laboratory mice.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333606 | PMC |
| http://dx.doi.org/10.5625/lar.2018.34.4.311 | DOI Listing |
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