Expression and gene regulation network of in hepatocellular carcinoma based on data mining.

RNA binding motif protein 8A (RBM8A) is an RNA binding protein in a core component of the exon junction complex. Abnormal expression is associated with carcinogenesis. We used sequencing data from the Cancer Genome Atlas database and Gene Expression Omnibus, analyzed expression and gene regulation networks in hepatocellular carcinoma (HCC). Expression was analyzed using Oncomine and Gene Expression Profiling Interactive Analysis tools, while alterations and related functional networks were identified using cBioPortal. LinkedOmics was used to identify differential gene expression with and to analyze Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways. Gene enrichment analysis examined target networks of kinases, miRNAs and transcription factors. We found that is overexpressed and the gene often amplified in HCC. Expression of this gene is linked to functional networks involving the ribosome and RNA metabolic signaling pathways. Functional network analysis suggested that regulates the spliceosome, ribosome, DNA replication and cell cycle signaling via pathways involving several cancer-related kinases, miRNAs and E2F Transcription Factor 1. Our results demonstrate that data mining efficiently reveals information about expression and potential regulatory networks in HCC, laying a foundation for further study of the role of in carcinogenesis.