AI Article Synopsis
- Ketorolac is recognized for providing effective postoperative pain relief after spinal surgery while potentially reducing the need for opioids, but its impact on spinal fusion outcomes remains unclear and requires further research.
- The study is a rigorous, multicenter trial that aims to assess the effects of ketorolac on fusion rates, opioid use, pain levels, and hospital stay duration compared to a placebo.
- Ethical approval has been secured, and findings will be submitted to academic journals, aiming to contribute valuable data to the ongoing discussion about ketorolac's role in spinal surgery recovery.
Article Abstract
Introduction: Ketorolac has been shown to provide quality postoperative pain control and decrease opioid requirement with minimal side effects following spinal surgery. However, the literature addressing its use in spinal fusions is highly variable in both its effectiveness and complications, such as pseudarthrosis. Recent literature postulates that ketorolac may not affect fusion rates and large randomised controlled trials are needed to demonstrate ketorolac as a safe and effective adjuvant treatment to opioids for postoperative pain control.
Methods And Analysis: This is a multihospital, prospective, double-blinded, randomised placebo-controlled trial. Data concerning fusion rates, postoperative opioid use, pain scores, length of stay will be recorded with the aim of demonstrating that the use of ketorolac does not decrease thoracolumbar spinal fusion rates while identifying possible adverse events related to short-term minimal effective dose compared with placebo. Additionally, this investigation aims to demonstrate a decrease in postoperative opioid use demonstrated by a decrease in morphine equivalence while showing equivalent postoperative pain control and decrease the average length of stay.
Ethics And Dissemination: Ethical approval was obtained at all participating hospitals by the institutional review board. The results of this study will be submitted for publication in peer-reviewed journals.
Trial Registration Number: NCT03278691.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347897 | PMC |
| http://dx.doi.org/10.1136/bmjopen-2018-025855 | DOI Listing |
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