Tedizolid is a novel oxazolidinone with activities against Gram-positive microorganisms, including mycobacteria. We studied the activity of tedizolid against 120 strains, including susceptible, first-line-resistant, and multidrug-resistant isolates. MIC was tested using the Bactec 960 MGIT system. MIC and MIC were 0.5 and 0.25 μg/ml, respectively, in susceptible and resistant strains. Tedizolid may be an alternative in the treatment of resistant .
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437524 | PMC |
| http://dx.doi.org/10.1128/AAC.01939-18 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Oxazolidinone antibiotics impair megakaryocyte differentiation from hematopoietic progenitor cells and their maturation into platelets.
Antimicrob Agents Chemother
October 2024
Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain (UCLouvain), Brussels, Belgium.
Article Synopsis
- Oxazolidinones, like linezolid and tedizolid, can cause adverse reactions, particularly thrombocytopenia, due to their impact on mitochondrial function, though the exact mechanism is still unclear.
- * In experiments with human CD34+ cells, oxazolidinones significantly reduced burst-forming unit-erythroid (BFU-E) colony formation and disrupted the differentiation of megakaryocytes, affecting their typical maturation and structure.
- * The toxicity observed was more severe with tedizolid compared to linezolid, suggesting that mitochondrial dysfunction plays a crucial role in thrombocytopenia, which complicates potential pharmacological solutions for this side effect.
Tedizolid phosphate alleviates DSS-induced ulcerative colitis by inhibiting senescence of cell and colon tissue through activating AMPK signaling pathway.
Int Immunopharmacol
June 2024
School of Basic Medicine, Dali University, Dali 671000, Yunnan, China. Electronic address:
Article Synopsis
- Ulcerative colitis (UC) is an inflammatory bowel disease that may be worsened by cellular senescence, although their relationship is not fully understood.
- New research shows that the compound Tedizolid Phosphate (TED) can combat senescence in colon cells affected by the UC inducer dextran sulfate sodium (DSS).
- TED not only alleviated UC symptoms and colon senescence in mice but also worked by restoring AMPK signaling, suggesting that targeting senescence might be a promising treatment strategy for UC.
Identification of an Enterococcus faecium strain isolated from raw bovine milk co-harbouring the oxazolidinone resistance genes optrA and poxtA in China.
Vet Microbiol
June 2024
State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China. Electronic address:
Oxazolidinones are potent antimicrobial agents used to treat human infections caused by multidrug-resistant Gram-positive bacteria. The growing resistance to oxazolidinones poses a significant threat to public health. In August 2021, a linezolid-resistant Enterococcus faecium BN83 was isolated from a raw milk sample of cow in Inner Mongolia, China.
View Article and Find Full Text PDFFDA-Approved Tedizolid Phosphate Prevents Cisplatin-Induced Hearing Loss Without Decreasing Its Anti-tumor Effect.
J Assoc Res Otolaryngol
June 2024
Medical Science and Technology Innovation Center, Shandong First Medical University, Jinan, 250117, China.
Purpose: Cisplatin is a low-cost clinical anti-tumor drug widely used to treat solid tumors. However, its use could damage cochlear hair cells, leading to irreversible hearing loss. Currently, there appears one drug approved in clinic only used for reducing ototoxicity associated with cisplatin in pediatric patients, which needs to further explore other candidate drugs.
View Article and Find Full Text PDFIn vitro activity of tedizolid against 43 species of Nocardia species.
Sci Rep
March 2024
Department of Laboratory Medicine, Fukushima Medical University, 1 Hikariga-Oka, Fukushima City, Fukushima, 960-1295, Japan.
The purpose of the present study was to evaluate the in vitro activity of tedizolid against several clinically significant species of Nocardia by comparing with that of linezolid. A total of 286 isolates of Nocardia species, including 236 clinical isolates recovered from patients in Japan and 50 strains (43 species) purchased from NITE Biological Resource Center, were studied. Antimicrobial susceptibility testing was performed using the broth microdilution method.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!