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Congenital nevi with hypomelanosis and fine scales. | LitMetric
Background : Nevus is a hamartoma or malformation of one or more skin components, resulting in aberrant differentiation of the cell lineage(s) mostly during developmental stages. Although multiple lineages may be involved in a nevus, the combination of melanocyte and keratinocyte abnormalities has been rarely discussed.Objectives : To present two cases of congenital nevi with hypomelanosis and superficial fine scales.Materials & Methods : Skin specimens of the patients were analysed by immunohistochemistry and electron microscopy.Results : Morphological and immunohistochemical studies indicated aberrant epidermal differentiation in the lesional skin specimens. Electron microscopy showed defective melanosome maturation in the melanocytes of the nevi samples.Conclusion : These results demonstrate that both epidermal and melanocytic lineages can concomitantly contribute to the formation of a nevus lesion.
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