AI Article Synopsis
- Zinc-α2-glycoprotein (ZAG) is a fat-regulating protein linked to issues with glucose and fat metabolism in metabolic disorders, and thyroid hormones are thought to boost its production in the liver.
- The study involved 120 hyperthyroid patients and 122 healthy controls, with some patients receiving methimazole treatment for two months to assess changes in ZAG levels.
- Results showed higher ZAG levels in hyperthyroid patients, which correlated positively with thyroid hormones and negatively with cholesterol levels, decreasing after methimazole treatment, suggesting ZAG's role in lipid metabolism disorders in hyperthyroidism.
Article Abstract
Background: Zinc-α2-glycoprotein (ZAG) is a recently novel lipolytic adipokine implicated in regulation of glucose and lipid metabolism in many metabolic disorders. In vitro and animal studies suggest that thyroid hormones (TH) up-regulates ZAG production in hepatocytes. However, there is no data evaluating the possible relationship between ZAG and TH in a human model of hyperthyroidism. The objective of the present study is to assess the association of serum ZAG levels with TH and lipid profile in patients with hyperthyroidism before and after methimazole treatment.
Methods: A total of 120 newly diagnosed overt hyperthyroidism and 122 healthy control subjects were recruited. Of them, 39 hyperthyroidism patients were assigned to receive methimazole treatment as follow-up study for 2 months.
Results: The clinical consequence showed that serum ZAG levels were elevated in patients with hyperthyroidism (P < 0.01). Adjust for age, gender and BMI, serum ZAG levels were positively related with serum free T3 (FT3), free T4 (FT4) levels and negatively correlated with serum total cholesterol (TC), low density lipoprotein cholesterol (LDLC) levels in hyperthyroidism subjects (all P < 0.01). After methimazole treatment, serum ZAG levels were decreased and the decline was associated with decreased FT3, FT4 and increased TC levels (all P < 0.001).
Conclusion: We conclude that ZAG may be involved in the pathogenesis of lipid metabolism disorder in patients with hyperthyroidism.
Trial Registration: ChiCTR-ROC-17012943 . Registered 11 October 2017, retrospectively registered.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343254 | PMC |
| http://dx.doi.org/10.1186/s12902-019-0336-9 | DOI Listing |
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