Objectives: This study aimed to investigate the predictive value of cognitive/functional measures in combination with hippocampal volume (HCV) on the probability of conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD).
Methods: The Rey Auditory Verbal Learning Test for immediate memory, Mini-Mental State Examination, a functional assessment for independent daily activities and Alzheimer's Disease Assessment Scale were used as cognitive/functional measures and HCV as neuroimaging measure. Logistic regression and Cox proportional hazard analyses were used to explore the measures' predictive values for AD conversion and time to conversion.
Results: The probability of conversion from MCI to AD was associated with cognitive function, but this was moderated by HCV: higher at lower HCV and lower at higher HCV. General cognitive/functional measures were less predictive than immediate memory in predicting time to conversion to AD at small HCVs.
Conclusion: Effectiveness of cognitive measures and subtle functional abnormality in predicting conversion from MCI to AD is dependent on HCV, thus combined evaluation should be considered. A combination of HCV and immediate memory appear to perform best in predicting time to conversion.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424277 | PMC |
| http://dx.doi.org/10.1093/geronb/gbz011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The effectiveness of psychologically-informed physiotherapy for people with neck pain and the mediating role of illness perceptions: a replicated single-case experimental design study.
Disabil Rehabil
January 2025
Amsterdam Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Purpose: (1) To evaluate the effectiveness of personalised psychologically-informed physiotherapy in people with neck pain; (2) To explore the mediating role of changes in illness perceptions.
Method: In this replicated single-case study, 14 patients with non-specific neck pain at risk for chronicity received a personalised intervention addressing unhelpful illness perceptions and dysfunctional movement behaviour, according to principles of cognitive functional therapy. Outcomes included the mediating role of illness perceptions on overall effect, function, pain intensity and self-efficacy.
The Moderating Role of Online Awareness in the Association between Strategy Use and Performance Accuracy on a Test of Functional Cognition in Individuals with Acquired Brain Injury.
Arch Clin Neuropsychol
December 2024
Physiotherapy (Occupational Therapy) Department, Health Science School, University of Málaga, Málaga 29071, Spain, 29071.
Objective: Deficits in online self-awareness (SA) are common after acquired brain injury (ABI), leading to safety concerns and impacting daily activities and rehabilitation outcomes. Early identification is recommended as a critical first step in cognitive rehabilitation following ABI. The aim of this observational study was to examine differences in online SA and strategy use between individuals with ABI and healthy controls.
View Article and Find Full Text PDF[Assessment of Risk Factors for Reinsertion of Indwelling Urinary Catheters Despite Intervention for Voiding Disturbances by the Urination Care Team].
Hinyokika Kiyo
October 2024
The Department of Urology, Kyoto Katsura Hospital.
Article Synopsis
- * The study analyzed data from 98 patients at Kyoto Katsura Hospital, discovering that age, cognitive function upon admission, and high residual urine levels were key factors influencing whether patients needed their catheters reinserted.
- * Results showed that nearly half of the patients could urinate independently by discharge, with overall improvements in motor and functional scores, but cognitive scores did not significantly change.
Current Physiotherapy Assessment and Treatment Practices for Low Back Pain in Nigeria: A National Survey.
Physiother Res Int
January 2025
School of Allied Health, Human Services & Sport, La Trobe University, Melbourne, Australia.
Article Synopsis
- Despite advances in physiotherapy for Low Back Pain (LBP), Nigerian physiotherapists largely do not follow international guidelines for assessment and treatment of the condition.
- A survey of 267 registered physiotherapists revealed that while traditional assessment methods are commonly used, there is a significant lack of screening for serious issues and psychological distress.
- Most physiotherapists showed a strong interest in learning modern, evidence-based practices, indicating a desire for improved methods in managing LBP.
onitoring drug fficacy through ulti-mics esearch initiative in lzheimer's isease (MEMORI-AD): A protocol for a multisite exploratory prospective cohort study on the drug response-related clinical, genetic, microbial and metabolomic signatures in Filipino patients with Alzheimer's disease.
BMJ Open
November 2024
Mutli-Omics Research Program for Health, University of the Philippines Manila College of Medicine, Manila, Metro Manila, Philippines.
Introduction: Dementia is one of the leading causes of disability among older people aged 60 years and above, with majority eventually being diagnosed with Alzheimer's disease (AD). Pharmacological agents approved for dementia include acetylcholinesterase enzyme (AChE) inhibitors like rivastigmine, donepezil and galantamine and the N-methyl-D-aspartate (NMDA) receptor antagonist memantine, prescribed as monotherapy or in combination with each other, depending on the severity of disease. There is currently no available study demonstrating the clinical response to these drugs for AD in the Filipino population.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!