AI Article Synopsis
- The plant kingdom offers a vast resource for discovering new anticancer treatments, particularly through targeting epithelial-mesenchymal transition (EMT).
- This review highlights various bioactive phytochemicals that display anti-EMT activity, focusing on their potential in cancer therapy.
- Phenylpropanoids emerged as the most researched group in early studies, showing promise as anticancer agents, but more clinical evidence is needed to support their effectiveness.
Article Abstract
Background: The plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery.
Purpose: In this view, epithelial-mesenchymal transition (EMT) represents a novel and major target in anticancer therapy. Therefore, this narrative review aims to provide an updated overview on the bioactive phytochemicals with anti-EMT activity.
Conclusion: Among the plant products reviewed, phenylpropanoids were the most investigated at preclinical phase, thus exhibiting a promising potential as anticancer drugs, though an evidence-based clinical efficacy is still lacking.
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| http://dx.doi.org/10.1016/j.phymed.2018.07.001 | DOI Listing |
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