Race and poverty are poignant factors in how individuals and communities experience the world. The reality is that more people of color than White people live in poverty (Milner, 2013). How these inequalities intersect with the mind and environment is of compelling importance. The experiences of race and living in poverty are riddled with innumerable stressors and barriers, and as a result are subject to the experience of a range of mental health issues. Those that live the experience of trauma related to race and poverty suffer disproportionately from a host of hardships that contribute to psychological distress that can have a profound effect on mental health and serve as intrapsychic binds. These internalized weights require therapeutic supports to alleviate the internal oppressive circumstances by those that are immersed in the experience on a daily basis. This article explores the intersection of these psychological binds and their effect on human behavior.
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http://dx.doi.org/10.1080/19371918.2018.1562401 | DOI Listing |
J Microbiol Biotechnol
November 2024
Department of Biotechnology and Department of Integrative Food, Bioscience and Biotechnology (BK21 FOUR), Chonnam National University, Gwangju 61186, Republic of Korea.
This study investigates the modulatory effects of nicergoline, a major bioactive compound derived from ergot fungus, on the 5-hydroxytryptamine 3A (5-HT3A) receptor. Utilizing a two-electrode voltage-clamp technique, we evaluated the impact of nicergoline on the 5-HT-induced inward current (I) in 5-HT3A receptors. Our findings reveal that nicergoline inhibits I in a reversible and concentration-dependent manner.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California 93106, United States.
Electrochemical aptamer-based (EAB) sensors are a molecular measurement platform that enables the continuous, real-time measurement of a wide range of drugs and biomarkers in situ in the living body. EAB sensors are fabricated by depositing a thiol-modified, target-binding aptamer on the surface of a gold electrode, followed by backfilling with an alkanethiol to form a self-assembled monolayer. And while the majority of previously described EAB sensors have employed hydroxyl-terminated monolayers, a handful of studies have shown that altering the monolayer headgroup can strongly affect sensor performance.
View Article and Find Full Text PDFNutrients
December 2024
Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.
Chronic stress exposure has been widely recognized as a significant contributor to numerous central nervous system (CNS) disorders, leading to debilitating behavioral changes such as anxiety, depression, and cognitive impairments. The prolonged activation of the hypothalamic-pituitary-adrenal (HPA) axis during chronic stress disrupts the neuroendocrine balance and has detrimental effects on neuronal function and survival. () Gaertn.
View Article and Find Full Text PDFSci Adv
January 2025
Department of Medical Genetics, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Protein translation is crucial for fear extinction, a process vital for adaptive behavior and mental health, yet the underlying cell-specific mechanisms remain elusive. Using a Tet-On 3G genetic approach, we achieved precise temporal control over protein translation in the infralimbic medial prefrontal cortex () during fear extinction. In addition, our results reveal that the disruption of cytoplasmic polyadenylation element binding protein 1 (Cpeb1) leads to notable alterations in cell type-specific translational programs, thereby affecting fear extinction.
View Article and Find Full Text PDFPsychol Rev
January 2025
Department of Psychological and Brain Sciences, Dartmouth College.
Our premodern ancestors had perceptual, motoric, and cognitive functional domains that were modularly encapsulated. Some of these came to interact through a new type of cross-modular binding in our species. This allowed previously domain-dedicated, encapsulated motoric and sensory operators to operate on operands for which they had not evolved.
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