AI Article Synopsis
- Researchers have developed a tetrahedral assembly that can differentiate between anionic and neutral substances in water, addressing a challenge in supramolecular chemistry.
- The assembly's effectiveness is enhanced by including an anionic template or creating a stable covalent structure with tris(2-aminoethyl)amine (TREN).
- This water-soluble and fluorescent cage can bind important biological molecules like nucleotides, making it useful for detecting toxins and drugs in aqueous environments.
Article Abstract
The design of aqueous probes and binders for complex, biologically relevant anions presents a key challenge in supramolecular chemistry. Herein, a tetrahedral assembly with cationic faces and corners is reported that is capable of discriminating between anionic and neutral guests in water. Electrostatic repulsion between subcomponents can be overcome by the addition of an anionic template, or generating a robust covalent framework by incorporating tris(2-aminoethyl)amine (TREN). The resultant TREN-capped, water-soluble, fluorescent cage binds mono- and poly-phosphoric esters, including nucleotides. Its covalent skeleton renders it stable at micromolar concentrations in water, enabling the fluorometric detection of biologically relevant guests in an aqueous environment. Selective supramolecular encapsulants, such as 1, could enable new sensing applications, such as recognition of toxins and drugs, under biological conditions.
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| http://dx.doi.org/10.1002/anie.201814149 | DOI Listing |
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