Association analysis of polymorphisms in and near in Alzheimer's disease patients carrying the ε4 Allele.

Background And Purpose: Lipid metabolism plays an important role in Alzheimer's disease (AD), and recent evidence suggests that single nucleotide polymorphisms (SNPs) in the StAR-related lipid transfer domain 6 () and near the enzyme enoyl CoA hydratase domain containing 3 () gene are related to plasma lipid levels or lipid traits in AD.

Materials And Methods: To identify whether the variants in or near the and genes contribute to AD susceptibility, we carried out an association analysis of rs10164112 and rs7920721 in combination with the apolipoprotein E () ε4 allele in a case-control study (278 cases, 509 controls) in China.

Results: We identified that SNP rs10164112 in the gene was a risk factor associated with AD and the ε4 carriers (all <0.05) after Bonferroni correction. However, multivariate logistic regression analysis indicated that only the minor T allele of rs10164112 combined with the ε4 allele increased the risk of AD under the additive and dominant models (additive model: =0.0078, OR=1.988, 95 % CI: 1.198-3.298; dominant model: =0.0172, OR=2.169, 95% CI: 1.147-4.102).

Conclusion: These results suggest that the rs10164112-T allele is not an independent risk factor for AD patients. However, in combination with the ε4 allele, the rs10164112-T allele has been found to be a risk factor for AD in the Han Chinese population reported in this study.