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Higher Tumor/Organ Accumulation Ratio of Porous Dual Infinite Coordination Polymer Nanocomposites for Efficient Tumor Photothermal-Starvation-Dual Hypoxia Chemo Synergistic Therapy.
Small
December 2024
Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
To enhance tumor comprehensive therapeutic effect of nanomedicines, an efficient strategy that integrates polydopamine and IR780 photothermal therapy, glucose oxidase (GOx) starvation therapy, Banoxantrone (AQ4N) and Tirapazamine (TPZ) dual hypoxia chemotherapy is developed in chronological order. Higher tumor accumulation of porous dual infinite coordination polymer nanocomposites are designed and prepared to implement this strategy, in which fluorescent dye IR780 doped hypoxic prodrugs AQ4N and TPZ coordinated with Cu(II) as the core, this core is encapsulated by GOx-loaded porous polydopamine coordinated with Fe(III) (Fe-MPDA). These nanocomposites exhibit a particle dimension of 118.
View Article and Find Full Text PDFCrosstalk between gut microbiota and cancer chemotherapy: current status and trends.
Discov Oncol
December 2024
Department of Traditional Chinese Medicine, Peking University First Hospital, Beijing, China.
Background: Chemotherapy is crucial in the management of tumors, but challenges such as chemoresistance and adverse reactions frequently lead to therapeutic delays or even premature cessation. A growing body of research underscores a profound connection between the gut microbiota (GM) and cancer chemotherapy (CC). This paper aims to pinpoint highly influential publications and monitor the current landscape and evolving trends within the realm of GM/CC research.
View Article and Find Full Text PDFMicrobiome composition and turnover in the face of complex lifecycles and bottlenecks: insights through the study of dung beetles.
Appl Environ Microbiol
December 2024
Department of Biology, Indiana University Bloomington, Bloomington, Indiana, USA.
Unlabelled: Microbiome composition and function often change throughout a host's life cycle, reflecting shifts in the ecological niche of the host. The mechanisms that establish these relationships are therefore important dimensions of host ecology and evolution; yet, their nature remains poorly understood. Here, we sought to investigate the microbial communities associated with the complex life cycle of the dung beetle and the relative contributions of host life stage, sex, and environment in determining microbiome assembly.
View Article and Find Full Text PDFEffect of preconception antibiotics exposure on female reproductive health and pregnancy outcomes: a systematic review and meta-analysis.
EClinicalMedicine
December 2024
Department of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Background: The preconception period is a window of opportunity to influence maternal and pregnancy outcomes. Inappropriate use of antibiotics results in gut dysbiosis and may affect host reproductive health through multiple dimensions. Animal studies demonstrate that antibiotic treatment profoundly affects ovarian functions and the estrous cycle, and it has a direct implication for infertility.
View Article and Find Full Text PDFUnraveling the role of cancer-associated fibroblasts in colorectal cancer.
World J Gastrointest Oncol
December 2024
Department of Pathology, Shandong Second Medical University, Weifang 261053, Shandong Province, China.
Within the intricate milieu of colorectal cancer (CRC) tissues, cancer-associated fibroblasts (CAFs) act as pivotal orchestrators, wielding considerable influence over tumor progression. This review endeavors to dissect the multifaceted functions of CAFs within the realm of CRC, thereby highlighting their indispensability in fostering CRC malignant microenvironment and indicating the development of CAFs-targeted therapeutic interventions. Through a comprehensive synthesis of current knowledge, this review delineates insights into CAFs-mediated modulation of cancer cell proliferation, invasiveness, immune evasion, and neovascularization, elucidating the intricate web of interactions that sustain the pro-tumor metabolism and secretion of multiple factors.
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