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Maternal Allergic Disease Phenotype and Infant Birth Season Influence the Human Milk Microbiome.
Allergy
December 2024
School of Molecular Sciences, The University of Western Australia, Crawley, WA, Australia.
Early infancy is a critical period for immune development. In addition to being the primary food source during early infancy, human milk also provides multiple bioactive components that shape the infant gut microbiome and immune system and provides a constant source of exposure to maternal microbiota. Given the potential interplay between allergic diseases and the human microbiome, this study aimed to characterise the milk microbiome of allergic mothers.
View Article and Find Full Text PDFNon-traditional risk factors for atrial fibrillation: epidemiology, mechanisms, and strategies.
Eur Heart J
December 2024
Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, No. 639, Zhizaoju Road, Huangpu District, Shanghai 200011, China.
Atrial fibrillation (AF) has become the pre-dominant arrhythmia worldwide and is associated with high morbidity and mortality. Its pathogenesis is intricately linked to the deleterious impact of cardiovascular risk factors, emphasizing the pivotal imperative for early detection and mitigation strategies targeting these factors for the prevention of primary AF. While traditional risk factors are well recognized, an increasing number of novel risk factors have been identified in recent decades.
View Article and Find Full Text PDFUrban Greening and Pollen Allergy: Balancing Health and Environmental Sustainability.
J Allergy Clin Immunol Pract
December 2024
Institute of Allergology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Immunology and Allergology, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Berlin, Germany. Electronic address:
Urban living requires a careful balance between human health and environmental sustainability when selecting urban vegetation. Public gardens and green roofs offer significant environmental benefits, including air filtration, exposure to health-associated microbiota, and mitigation of the urban heat island effect. However, prioritizing allergy-friendly species is crucial to prevent the exacerbation of pollen allergies.
View Article and Find Full Text PDFA gut commensal protozoan determines respiratory disease outcomes by shaping pulmonary immunity.
Cell
December 2024
Department of Immunology, University of Toronto, Toronto, ON, Canada. Electronic address:
The underlying mechanisms used by the intestinal microbiota to shape disease outcomes of the host are poorly understood. Here, we show that the gut commensal protozoan, Tritrichomonas musculis (T.mu), remotely shapes the lung immune landscape to facilitate perivascular shielding of the airways by eosinophils.
View Article and Find Full Text PDFLink between respiratory microbiota and asthma: an emerging therapeutic approach.
Am J Transl Res
November 2024
Department of Respiratory Medicine, The First Affiliated Hospital, Heilongjiang University of Chinese Medicine Harbin 150040, Heilongjiang, China.
The respiratory microbiota significantly influence the onset and progression of asthma, as underscored by recent studies revealing discernible differences between asthma patients and healthy individuals. This review delves into the relationship between respiratory microbiota and asthma, with a particular emphasis on possible therapeutic targets and emerging treatments. Existing research is thoroughly synthesized, illuminating the association between microbial communities and the incidence of asthma.
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