A new -pyrone derivative, acrepyrone A (), and three known sorbicillinoids, trichodimerol (), dihydrotrichodimerol () and tetrahydrotrichodimerol () were isolated from an endophytic fungus, SS-g13, harboured in the roots of the Chinese medicinal plant Their structures were determined by analysing MS, NMR, and ECD data. Compound was evaluated for its cytotoxic effect, antibacterial activity and quorum sensing inhibitory potential.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1080/14786419.2018.1548462 | DOI Listing |
RSC Adv
January 2025
Department of Organic Chemistry, Faculty of Chemistry, Alzahra University Vanak Tehran 1993893973 Iran
In this work, we present an efficient strategy for the straightforward synthesis of functionalized 1,6-dihydropyridine derivatives a three-component reaction of 3-vinylchromones, aromatic aldehydes, and ammonium acetate. A tandem procedure including NH aldimine formation/Michael-type addition/opening of the pyrone ring/isomerization/6π-electrocyclization/[1,5]-H shift allows rapid access to a series of dihydropyridines bearing an -hydroxybenzoyl and a benzoyl scaffold in good yields. Readily available precursors, simple heating conditions, and operational simplicity are some highlighted advantages of this transformation.
View Article and Find Full Text PDFPlanta Med
January 2025
Instituto de Química, Departamento de Productos Naturales, Universidad Nacional Autónoma de México, Mexico City, Mexico.
An approach combining enzymatic inhibition and untargeted metabolomics through molecular networking was employed to search for human recombinant full-length protein tyrosine phosphatase 1B (PTP1 B) inhibitors from a collection of 66 mangrove-associated fungal taxa. This strategy prioritized two strains (IQ-1612, section , and IQ-1620, section ) for further studies. Chemical investigation of strain IQ-1612 resulted in the isolation of a new nonanolide derivative, roseoglobuloside A (1: ), along with two known metabolites (2: and 3: ), whereas strain IQ-1620 led to the isolation of four known naphtho-γ-pyrones and one known diketopiperazine (4: -8: ).
View Article and Find Full Text PDFACS Omega
January 2025
Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB NOVA), Av. da República, 2780-157, Oeiras, Portugal.
Sporopollenin is a plant polymer present in the exine of the pollen grains that comprises two layers: the endexine and the ektexine. It possesses remarkable mechanical, thermal, and chemical stability and is also highly recalcitrant to hydrolysis. The chemical backbone of sporopollenin mostly consists of a polyhydroxylated aliphatic component and polyketide-derived aliphatic α-pyrone elements.
View Article and Find Full Text PDFOrg Lett
January 2025
Department of Chemistry, Xihua University, Chengdu 610039, P. R. China.
A novel approach for the synthesis of pyrone and indanone derivatives utilizing Fe(III)-catalyzed reductive radical ring expansion of olefins and cyclopropenone has been proposed. The preliminary mechanism study shows that the alkyl radical is formed by hydrogen atom transfer, which can open the tension ring and then generate the intermediate. There are two paths for the intermediate: when there is a hydroxyl group at the β-position of the olefin, the reaction produces pyrones, and otherwise 1-indanone is generated.
View Article and Find Full Text PDFJ Agric Food Chem
January 2025
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Sanya Oceanographic Institute, Ocean University of China, Qingdao 266003, People's Republic of China.
, a common foodborne pathogen, has a close association with agriculture and food. With the rapid emergence and widespread dissemination of antimicrobial resistance, efforts have been directed toward developing and studying new antimicrobial compounds to inhibit the growth of and other foodborne pathogens, thereby preventing contamination and ensuring food safety. Herein, we reported eight new aromatic polyketides, naphpyrones A-H (-), from the heterologous expression strain A3(2)/ ΔH3.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!