AI Article Synopsis
- DNA methylation is a process that helps control how genes work in mammals, and this study looks at how genetics, gender, and pregnancy affect it in mice.
- Researchers crossed two different types of mice and checked their DNA to see how their methylation patterns changed, finding many differences between them.
- The study shows that some DNA changes can be passed down to the next generation, and that female mice who had babies show unique changes in their DNA that might help record important life events.
Article Abstract
DNA methylation is an essential epigenetic process in mammals, intimately involved in gene regulation. Here we address the extent to which genetics, sex, and pregnancy influence genomic DNA methylation by intercrossing 2 inbred mouse strains, C57BL/6N and C3H/HeN, and analyzing DNA methylation in parents and offspring using whole-genome bisulfite sequencing. Differential methylation across genotype is detected at thousands of loci and is preserved on parental alleles in offspring. In comparison of autosomal DNA methylation patterns across sex, hundreds of differentially methylated regions are detected. Comparison of animals with different histories of pregnancy within our study reveals a CpG methylation pattern that is restricted to female animals that had borne offspring. Collectively, our results demonstrate the stability of CpG methylation across generations, clarify the interplay of epigenetics with genetics and sex, and suggest that CpG methylation may serve as an epigenetic record of life events in somatic tissues at loci whose expression is linked to the relevant biology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338756 | PMC |
| http://dx.doi.org/10.1038/s41467-018-08067-z | DOI Listing |
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