Malaria is a major tropical disease where important needs are to mitigate symptoms and to prevent the establishment of infection. Cyclopeptides containing -methyl amino acids with activity against erythrocytic forms as well as liver stage are presented. The synthesis, parasitological characterization, physicochemical properties, evaluation, and mice pharmacokinetics are described.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331169 | PMC |
| http://dx.doi.org/10.1021/acsmedchemlett.8b00543 | DOI Listing |
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