We report the design, synthesis, and evaluation of novel 5-fluorouracil (5FU) prodrugs , that are efficiently activated by the high level of reactive oxygen species (ROS) in cancer cells. Prodrugs , selectively kill cancer cells over normal cells and are well-tolerated in mice. The strategy described herein can extend application of chemotherapeutic drugs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331168 | PMC |
| http://dx.doi.org/10.1021/acsmedchemlett.8b00539 | DOI Listing |
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