Better therapeutics are greatly needed to treat patients infected with trypanosomatid parasites such as or . This report describes 28 new imidazopyridines and triazolopyrimidines with potent and selective antitrypanosomal activity. Drug-like properties were demonstrated in a number of in vitro assays. In vivo efficacy was observed for and in acute mouse models of infection. Compounds and represent potential leads for new anti-Chagas disease drugs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331164 | PMC |
| http://dx.doi.org/10.1021/acsmedchemlett.8b00498 | DOI Listing |
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