High expression of density-regulated re-initiation and release factor drives tumourigenesis and affects clinical outcome.

Previously, certain experiments have suggested that density-regulated re-initiation and release factor () could serve important roles in cancer, however, to the best of our knowledge, a comprehensive analysis of and its association with cancer patient survival is lacking. The aim of the current study was to investigate the expression of in multiple tumour types and to evaluate the effects of on survival in malignancies. Sample expression profiles were downloaded from the Gene Expression Omnibus database. Association between expression and clinicopathological features was analysed by Chi-square tests. The effects of on survival were evaluated by Kaplan-Meier analysis. The results of the current study demonstrate that expression was upregulated in nine cancer types. High expression indicated poor prognosis of patients. The results of the present study demonstrated that is highly expressed in multiple tumour types and may be used as a potential prognostic marker and therapeutic target.