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Hepatopulmonary syndrome in biliary atresia children increased postoperative complications after liver transplantation.
Pediatr Neonatol
November 2024
Departments of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:
Background: Hepatopulmonary syndrome (HPS) is a complication in biliary atresia (BA) children following hepatoportoenterostomy. Liver transplantation (LT) was the definitive treatment of HPS. However, little was known about the risk factors between HPS and mortalities.
View Article and Find Full Text PDFCase report: Pediatric hepatopulmonary syndrome despite strict weight control after craniopharyngioma surgery.
Front Endocrinol (Lausanne)
November 2024
Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Childhood-onset craniopharyngiomas, though rare, are intracranial malformations that can cause obesity by disrupting the hypothalamus, a condition that often persists even after tumor resection. This severe obesity increases the risk of diabetes and fatty liver disease in childhood. Concurrently, panhypopituitarism, including growth hormone (GH) deficiency, may develop.
View Article and Find Full Text PDFHepatopulmonary syndrome secondary to metabolic associated fatty liver disease in childhood - novel treatment with growth hormone replacement therapy: a case report and systematic review of literature.
Front Endocrinol (Lausanne)
November 2024
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea.
Objective: Hepatopulmonary syndrome (HPS) is a rare complication of metabolic associated fatty liver disease (MAFLD) occurring subsequent to hypopituitarism, often developing after resection of hypothalamic or pituitary tumors. The aim of this study is to report an illustrative case of an HPS patient who was successfully treated with growth hormone replacement therapy, without liver transplantation which is conventionally regarded as the only treatment option. Additionally, we conducted a comprehensive review of published case reports of HPS in the pediatric population.
View Article and Find Full Text PDFHepatopulmonary syndrome associated with long-term use of ado-trastuzumab emtansine (T-DM1) for treatment of HER2-positive metastatic breast cancer - a case report and series.
Front Oncol
October 2024
Department of Oncology, Mayo Clinic, Rochester, MN, United States.
Article Synopsis
- ADCs in Cancer Therapy
- : Antibody-drug conjugates (ADCs), like ado-trastuzumab emtansine (T-DM1), are a significant breakthrough in cancer treatment, specifically for HER2-positive breast cancer, allowing targeted delivery of drugs to tumor cells while sparing normal tissue, but they can cause severe toxicity requiring monitoring.
- Hepatopulmonary Syndrome (HPS) Cases
- : A case series of four patients who received T-DM1 revealed they developed hepatopulmonary syndrome (HPS), which involves severe respiratory issues and is linked to long-term liver damage caused by the drug.
- Need for Awareness
- : The findings underscore the importance of recognizing
Radiation Pneumonitis after Yttrium-90 Radioembolization: A Systematic Review.
J Vasc Interv Radiol
October 2024
Diagnostic Imaging and Interventional Radiology, Moffitt Cancer Center, Tampa, Florida; Department of Radiology, Semmelweis University, Budapest, Hungary.
Purpose: To evaluate the available evidence of lung dosimetry and radiation pneumonitis (RP).
Materials And Methods: The guideline regarding the maximum tolerated lung dose for yttrium-90 (Y) radioembolization is an expert opinion (Level 5 evidence) based on a case series of 5 patients and recommends keeping the absorbed radiation dose to the lungs below 30 Gy per treatment and 50 Gy in a lifetime to prevent RP. The current understanding of the risks of RP is minimal despite its debilitating nature and high mortality rate.
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