AI Article Synopsis

  • ESBL-PE, recognized by the WHO as a critical public health threat, has not been thoroughly studied in food animals and humans in Sub-Saharan Africa, particularly in Cameroon and South Africa.
  • The research focused on determining the risk factors, prevalence, antimicrobial resistance, and genetic relationships of ESBL-PE among pigs and abattoir workers, revealing higher prevalence in Cameroon and identifying key risk factors affecting workers.
  • The study found a strong association between nasal and hand colonization of ESBL-PE in workers and recommends urgent strategies for controlling antibiotic resistance in the food supply chain.

Article Abstract

Extended spectrum β-lactamase-producing (ESBL-PE) represent a significant public health concern globally and are recognized by the World Health Organization as pathogens of critical priority. However, the prevalence of ESBL-PE in food animals and humans across the farm-to-plate continuum is yet to be elucidated in Sub-Saharan countries including Cameroon and South Africa. This work sought to determine the risk factors, carriage, antimicrobial resistance profiles and genetic relatedness of extended spectrum β-lactamase producing (ESBL-PE) amid pigs and abattoir workers in Cameroon and South Africa. ESBL-PE from pooled samples of 432 pigs and nasal and hand swabs of 82 humans were confirmed with VITEK 2 system. Genomic fingerprinting was performed by ERIC-PCR. Logistic regression (univariate and multivariate) analyses were carried out to identify risk factors for human ESBL-PE carriage using a questionnaire survey amongst abattoir workers. ESBL-PE prevalence in animal samples from Cameroon were higher than for South Africa and ESBL-PE carriage was observed in Cameroonian workers only. Nasal ESBL-PE colonization was statistically significantly associated with hand ESBL-PE (21.95% vs. 91.67%; = 0.000; OR = 39.11; 95% CI 2.02⁻755.72; = 0.015). Low level of education, lesser monthly income, previous hospitalization, recent antibiotic use, inadequate handwashing, lack of training and contact with poultry were the risk factors identified. The study highlights the threat posed by ESBL-PE in the food chain and recommends the implementation of effective strategies for antibiotic resistance containment in both countries.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470761PMC
http://dx.doi.org/10.3390/pathogens8010010DOI Listing

Publication Analysis

Top Keywords

south africa
16
extended spectrum
12
cameroon south
12
risk factors
12
esbl-pe
11
spectrum β-lactamase
8
β-lactamase producing
8
esbl-pe food
8
abattoir workers
8
africa esbl-pe
8

Similar Publications

With an obsolete livestock sector, Gabon relies on its huge hydrographic network rich in fish to supply its populations with animal proteins. This study aimed to conduct metal analyses in four fish species () frequently consumed by human populations in the Moyen-Ogooué and Haut-Ogooué Provinces of Gabon and infer the potential human health risks for those populations who rely on these freshwater produces as a source of proteins. Fish were sampled from Ezanga, Oguemoué, Onangué, Nguenè (Moyen-Ogooué) and Grand Poubara (Haut-Ogooué) Lakes during the high flow period (HF) and low flow period (LF) from 2021 to 2022, and analysed for seven heavy metals (HMs) using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES) techniques.

View Article and Find Full Text PDF

Granulomas, organized aggregates of immune cells which form in response to (), are characteristic but not exclusive of tuberculosis (TB). Despite existing investigations on TB granulomas, the determinants that differentiate host-protective granulomas from granulomas that contribute to TB pathogenesis are often disputed. Thus, the goal of this narrative review is to help clarify the existing literature on such determinants.

View Article and Find Full Text PDF

Now that it has been realized that viruses are ubiquitous, questions have been raised on factors influencing their diversity and distribution. For phytoviruses, understanding the interplay between plant diversity and virus species richness and prevalence remains cardinal. As both the amplification and the dilution of viral species richness due to increasing host diversity have been theorized and observed, a deeper understanding of how plants and viruses interact in natural environments is needed to explore how host availability conditions viral diversity and distributions.

View Article and Find Full Text PDF

The species complex (FLSC) currently comprises 11 phylogenetic species, including accepted names such as , , and , which have mostly been reported in association with citrus and coffee. Many varieties were documented by Wollenweber & Reinking (1935), which is indicative of a wider diversity of species within this group. The lack of type material in some cases, especially for the older names, means that definition by molecular phylogeny is very difficult.

View Article and Find Full Text PDF

species have commonly been reported as important plant pathogenic fungi with wide host ranges and geographic distributions. With the increase in the number of cryptic species being described, a comprehensive global taxonomic revision of the genus is required. The present study includes 399 isolates from 32 countries.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: