AI Article Synopsis
- HIV antigens can be detected in individuals with HIV infection even before antibodies develop or after they decline during late-stage infection.
- Researchers tested plasma samples and cell extracts from HIV-positive individuals and healthy donors to improve the detection of these antigens.
- All infected subjects tested positive for HIV antigens in at least one sample type, while none of the healthy donors tested positive, suggesting this method could help in unclear antibody test cases.
Article Abstract
Antigenaemia due to human immunodeficiency virus (HIV) is thought to be significant either before the appearance of a specific antibody response, or after its decline during terminal stages. In order to increase the rate of detection of HIV antigen carriers, regardless of the stage or despite the presence of specific serum antibodies, we assayed, simultaneously, plasma samples and extracts from resting and phytohaemagglutinin-stimulated mononuclear cells from 25 infected, anti-body-positive individuals and 10 healthy, antibody-negative female volunteer blood donors. We detected the presence of HIV antigen in at least one of the three types of specimens obtained from all the 25 infected subjects but in none of the 10 healthy blood donors. This approach might prove most useful for the study of patients with controversial or equivocal antibody test results.
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| http://dx.doi.org/10.1016/0166-0934(88)90115-2 | DOI Listing |
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