AI Article Synopsis
- The study aimed to evaluate the effectiveness of soluble urokinase-type plasminogen activator receptor as a predictor of mortality after ICU discharge.
- Among the 202 patients studied, 18.6% died post-discharge, with nonsurvivors generally being older and more critically ill at admission, requiring more intensive treatments.
- Results indicated that while several markers were evaluated, SOFA scores were the most reliable indicator of in-hospital mortality, while the soluble urokinase-type plasminogen activator receptor was found to be a poor predictor.
Article Abstract
Objective: To determine the performance of soluble urokinase-type plasminogen activator receptor upon intensive care unit discharge to predict post intensive care unit mortality.
Methods: A prospective observational cohort study was conducted during a 24-month period in an 8-bed polyvalent intensive care unit. APACHE II, SOFA, C-reactive protein, white cell count and soluble urokinase-type plasminogen activator receptor on the day of intensive care unit discharge were collected from patients who survived intensive care unit admission.
Results: Two hundred and two patients were included in this study, 29 patients (18.6%) of whom died after intensive care unit discharge. Nonsurvivors were older and more seriously ill upon intensive care unit admission with higher severity scores, and nonsurvivors required extended use of vasopressors than did survivors. The area under the receiver operating characteristics curves of SOFA, APACHE II, C-reactive protein, white cell count, and soluble urokinase-type plasminogen activator receptor at intensive care unit discharge as prognostic markers of hospital death were 0.78 (95%CI 0.70 - 0.86); 0.70 (95%CI 0.61 - 0.79); 0.54 (95%CI 0.42 - 0.65); 0.48 (95%CI 0.36 - 0.58); and 0.68 (95%CI 0.58 - 0.78), respectively. SOFA was independently associated with a higher risk of in-hospital mortality (OR 1.673; 95%CI 1.252 - 2.234), 28-day mortality (OR 1.861; 95%CI 1.856 - 2.555) and 90-day mortality (OR 1.584; 95%CI 1.241 - 2.022).
Conclusion: At intensive care unit discharge, soluble urokinase-type plasminogen activator receptor is a poor predictor of post intensive care unit prognosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334487 | PMC |
| http://dx.doi.org/10.5935/0103-507X.20180062 | DOI Listing |
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