AI Article Synopsis
- The study explores how a dissymmetrical aromatic oligoamide helix can self-assemble around linear amido-carbamate rods, utilizing its unique structure to bind specifically to different groups.
- Using structural and thermodynamic techniques, researchers examined how the helix interacts with dumbbell-shaped guest molecules, revealing insights into the binding mechanism.
- Kinetic studies involving H NMR showed that the threading and sliding of the helix are influenced by the guest's properties, highlighting the potential for these foldaxanes in creating complex and controlled supramolecular systems.
Article Abstract
We have investigated the self-assembly of a dissymmetrical aromatic oligoamide helix on linear amido-carbamate rods. A dissymmetric sequence bearing two differentiated ends is able to wrap around dissymmetric dumbbell guest molecules. Structural and thermodynamic investigations allowed us to decipher the mode of binding of the helix that can bind specifically to the amide and carbamate groups of the rod. In parallel kinetic studies of threading and sliding of the helix along linear axles were also monitored by H NMR. Results show that threading of a dissymmetrical host can be kinetically biased by the nature of the guest terminus allowing a preferential sense of sliding of the helix. The study presented below further demonstrates the valuable potential of foldaxanes to combine designed molecular recognition patterns with fine control of self-assembly kinetics to conceive complex supramolecular events.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/anie.201813125 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Improving Outcomes with Sequential Fixation Using Long-Threaded Screws for Valgus-Impacted Femoral Neck Fractures.
Medicina (Kaunas)
December 2024
Department of Orthopedic Surgery, Ajou University School of Medicine, Suwon 16499, Republic of Korea.
Valgus-impacted femoral neck fractures (OTA 31B1.1 and 31B1.2) are considered stable fractures with favorable outcomes compared to displaced fractures.
View Article and Find Full Text PDFMicrofluidic Thread-Based Analytical Platform for Reaction Screening Enabled by In Situ Thread Spray Mass Spectrometry.
Anal Chem
January 2025
Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.
This study describes a microfluidic thread-based analytical device (μTAD) capable of in situ mass spectrometric analysis for continuous flow reaction monitoring. Organic reaction screening is foundational to drug discovery. Microfluidic devices are of special interest here because they provide continuous reaction monitoring with advantages such as the use of smaller reagent volumes and short analysis times.
View Article and Find Full Text PDFTunable Mechanically Interlocked Semi-Crystalline Networks.
Angew Chem Int Ed Engl
December 2024
Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, P. R. China.
High-performance polymers based on dynamic chemistry have been widely explored for multi-field advanced applications. However, noncovalent sacrificial bond-mediated energy dissipation mechanism causes a trade-off between mechanical toughness and resilience. Herein, we achieved the synchronous boost of seemingly conflicting material properties including mechanical robustness, toughness and elasticity via the incorporation of mechanical chemistry into traditional semi-crystalline networks.
View Article and Find Full Text PDFA multi-scale framework for predicting α-cyclodextrin assembly on polyethylene glycol axles.
Soft Matter
November 2024
Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, USA.
Controlling the distribution of rings on polymer axles, such as α-cyclodextrin (αCD) on polyethylene glycol (PEG), is paramount in imparting robust mechanical properties to slide-ring gels and polyrotaxane-based networks. Previous experiments demonstrated that the functionalization of polymer ends could modulate the coverage of αCDs on PEG. To explore the design rule, we propose a multi-scale framework for predicting αCD assembly on bare and functionalized PEG.
View Article and Find Full Text PDFBispillar[5]arene-Based Slide-Ring Polyrotaxanation Enables Enhanced Toughness, Recyclability, Impact, and Puncture Resistance of Polyisoprene Elastomers.
ACS Appl Mater Interfaces
September 2024
College of Polymer Science & Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
Article Synopsis
- A series of slide-ring polyrotaxanes (SRPs) were created by blending a special compound (ditopic pillar[5]arene) with polyisoprene (PIP) without using solvents, followed by heating.
- Testing showed that adding just 1% of the pillar[5]arene notably improved the material's elongation, tensile strength, and toughness, making it much stronger than the original PIP.
- The materials also demonstrated enhanced resistance to impacts and punctures, can be recycled due to their physical connections, and benefit from a unique mechanism that spreads stress more effectively across the material.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!