AI Article Synopsis
- The study aims to evaluate the effectiveness of using D-dimer levels to detect venous thromboembolism (VTE) in severe trauma patients, as conventional reference values are lacking due to trauma-induced level increases.
- Researchers analyzed data from 455 trauma patients over several years, applying specific screening criteria (hospital stay, increasing D-dimer, and elevated D-dimer levels) to identify those at risk for VTE.
- Out of patients meeting the criteria, 34 were diagnosed with VTE via imaging, suggesting that the D-dimer screening criteria can help in efficiently identifying VTE in similar patient populations.
Article Abstract
Aim: Because severe trauma patients frequently manifest coagulopathy, it is extremely important to detect venous thromboembolism (VTE) in the acute phase. However, no reference value for D-dimer in post-traumatic VTE has been reported given the substantial increase in its levels after injury. Therefore, this study evaluates the ability of our screening criteria using D-dimer to detect VTE in severe trauma patients.
Methods: Trauma patients ( = 455) who were admitted to our emergency medical center during October 2011-June 2015 were included in this study. To prevent VTE, intermittent pneumatic compression was carried out in most patients. Our screening criteria included the following: (i) ≥5 days of hospital stay, (ii) increasing D-dimer levels across 3 measuring days, (iii) D-dimer levels ≥15 μg/mL. Patients who met these screening criteria underwent contrast-enhanced computed tomography (CE-CT) to detect VTE.
Results: During the study period, 108 cases satisfied the screening criteria; 73 of these underwent CE-CT, 34 of whom were diagnosed with VTE (positive predictive value, 46.6%). The median hospital stay on satisfying the screening criteria and before undergoing CE-CT was 7 and 10 days, respectively. No patient had VTE symptoms at the time of diagnosis. Also, none of the remaining 347 patients who did not satisfy the screening criteria had VTE symptoms.
Conclusion: The screening criteria using D-dimer presented herein can be used as reference for efficiently detecting VTE in severe trauma patients.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328915 | PMC |
| http://dx.doi.org/10.1002/ams2.375 | DOI Listing |
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