Mouse inoculation test (MIT) is a highly sensitive test for rabies diagnosis but slow and expensive. To detect rabies virus an in vitro technique using Neuro 2a cell culture (CC) was compared with MIT in two laboratories. In one laboratory, CC appeared to be on the whole more sensitive than MIT, nevertheless MIT was the only one to detect some positive samples. In the other laboratory, MIT was more sensitive. These results justify the use of CC for epidemiological diagnosis but emphasize the interest of MIT (the reference technique) for special cases.
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