Background: The identification of hypoxia inducible factor (HIF-1α) expression is helpful for the quantitative assessment of tumor hypoxia. The application of multimodal imaging techniques may play a part in the assessment of HIF-1α expression of cervical carcinoma.
Purpose: To investigate the correlations between multiple imaging parameters and HIF-1α expression of early cervical carcinoma and to determine whether tumor hypoxia can be predicted using multisequence imaging parameters.
Study Type: Prospective observational.
Population: One hundred patients with early cervical carcinoma.
Field Strength/sequences: 3.0 T MRI including intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) and dynamic contrast-enhanced (DCE) perfusion MRI sequences.
Assessment: DCE-MRI and IVIM DWI were performed for all patients. The imaging parameters included volume transfer constant (K ), rate constant (K ), extravascular extracellular volume fraction (V ), D, D*, and f.
Statistical Tests: The comparisons of imaging parameters between two independent groups were performed using the Mann-Whitney U-test. Multiple linear regression analysis was performed to determine the correlation between multiple imaging parameters and HIF-1α expression. The diagnostic ability of DCE-MRI, IVIM DWI, and the combination of two techniques for discriminating high-expression and low-expression groups were analyzed.
Results: The high-expression group had a lower K or K value than the low-expression group (P = 0.03; 0.02), while the high-expression group had a higher V value than the low-expression group (P = 0.03). The high-expression group had a higher D or f value than the low-expression group (P = 0.02; 0.02). K , K , D, V , and f values were independently correlated with HIF-1α expression. The sensitivity or accuracy of a combined method was higher than that of DCE-MRI or IVIM DWI individually (P = 0.03, 0.02; 0.04, 0.03).
Data Conclusion: The combination of DCE-MRI and IVIM DWI can improve the diagnostic ability of discriminating different HIF-1α expression levels for early cervical tumors.
Level Of Evidence: 1 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2019;50:918-929.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jmri.26604 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Down to size: Exploring the influence of plastic particle Dimensions on physiological and nervous responses in early-stage zebrafish.
Environ Pollut
June 2024
Research Unit in Environmental and Evolutionary Biology (URBE), Institute of Life, Earth & Environment, University of Namur, Rue de Bruxelles, 61-B-5000, Namur, Belgium.
The chorion is the first protective barrier set to prevent numerous pollutants from damaging the developing embryo. However, depending on their size, some nanoplastics (NPs) can pass through this barrier and reach the embryo, while all microplastics (MPs) remain on the outside. This study brings a straight approach to compare MPs and NPs, and assess their direct and indirect effects on zebrafish embryos and larvae.
View Article and Find Full Text PDFSpecific cyprinid HIF isoforms contribute to cellular mitochondrial regulation.
Sci Rep
October 2020
College of Fisheries, National Demonstration Center for Experimental Aquaculture Education, Huazhong Agricultural University, Wuhan, 430070, China.
Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of the cellular response to hypoxic stress. Two HIF-1α paralogs, HIF-1αA and HIF-1αB, were generated in euteleosts by the specific, third round of genome duplication, but one paralog was later lost in most families with the exception of cyprinid fish. How these duplicates function in mitochondrial regulation and whether their preservation contributes to the hypoxia tolerance demonstrated by cyprinid fish in freshwater environments is not clear.
View Article and Find Full Text PDFHypoxia inducible factor-1 knockout does not impair acute thermal tolerance or heat hardening in zebrafish.
Biol Lett
July 2020
Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, ON Canada, K1N 6N5.
Article Synopsis
- Heat hardening in fish refers to the ability to increase thermal tolerance after exposure to high temperatures, helping them adapt to extreme environments.
- The study focused on zebrafish lacking specific hypoxia-inducible factors (Hif-1), hypothesizing that these fish would show reduced thermal tolerance and diminished heat hardening.
- Contrary to expectations, both Hif-1 knockout and wild-type zebrafish showed similar thermal tolerance and heat hardening abilities, indicating that hypoxia tolerance and thermal tolerance are not functionally linked.
Hif-1α and Hif-2α regulate hemogenic endothelium and hematopoietic stem cell formation in zebrafish.
Blood
March 2018
Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
During development, hematopoietic stem cells (HSCs) derive from specialized endothelial cells (ECs) called hemogenic endothelium (HE) via a process called endothelial-to-hematopoietic transition (EHT). Hypoxia-inducible factor-1α (HIF-1α) has been reported to positively modulate EHT in vivo, but current data indicate the existence of other regulators of this process. Here we show that in zebrafish, Hif-2α also positively modulates HSC formation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!